Kurskiĭ M D, Shinlova O P, Fomin V P, Kosterin S A
Vopr Med Khim. 1988 Mar-Apr;34(2):113-7.
Effect of drugs (quinine, sigetine, isoverine and pachycarpine) stimulating uterine contraction on active and passive Ca2+ transport was studied in cow myometrium sarcolemma. Isoverine and pachycarpine at concentrations 10(-6)-10(-2) M did not affect the systems of Ca2+ transport. Quinine at concentrations above 10(-3) M decreased the rate of Mg2+ ATP-dependent accumulation of Ca2+ and stimulated passive elimination of the cation from vesicles due to an increase in unspecific permeability of myometrial sarcolemma. Sigetine (10(-6) = 10(-2) M) did not affect the Ca2+ passive transport but inhibited uncompetitively the Mg2+ ATP-dependent accumulation of Ca2+ in sarcolemmal vesicles. Effect of sigetine as a stimulator of the uterine contractile activity is apparently based on inhibition of the calcium pump in plasmatic membrane of myometrial cells.
研究了刺激子宫收缩的药物（奎宁、西吉丁、异维林和厚果槐碱）对牛子宫肌膜主动和被动Ca2+转运的影响。浓度为10(-6)-10(-2) M的异维林和厚果槐碱不影响Ca2+转运系统。浓度高于10(-3) M的奎宁降低了Mg2+ ATP依赖的Ca2+积累速率，并由于子宫肌膜非特异性通透性增加而刺激了阳离子从囊泡中的被动消除。西吉丁（10(-6)=10(-2) M）不影响Ca2+的被动转运，但非竞争性抑制了肌膜囊泡中Mg2+ ATP依赖的Ca2+积累。西吉丁作为子宫收缩活性刺激剂的作用显然基于对子宫肌细胞质膜钙泵的抑制。
