Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, IN, 47907, USA.
Department of Pathology, School of Medicine, University of California at San Diego, La Jolla, CA, USA.
J Small Anim Pract. 2021 Sep;62(9):765-774. doi: 10.1111/jsap.13350. Epub 2021 May 17.
To evaluate the clinical characteristics, treatment, outcome and potential association between non-infectious inflammatory myopathy and malignancy in boxer dogs.
Boxer dogs histologically diagnosed with non-infectious inflammatory myopathy at the Comparative Neuromuscular Laboratory, University of California San Diego from 2010 to 2018 and with complete medical records were included in this retrospective study. Signalment, history, clinical signs, clinicopathologic findings, treatment and outcome were documented.
Twenty-eight boxer dogs with non-infectious inflammatory myopathy, aged 1 to 11 years, were included. Eighteen were male (16 neutered; two entire) and 10 were female (seven spayed; three entire). Clinical signs included generalised weakness (n=17), dysphagia (n=11) and weight loss (n=10). Serum creatine kinase activity was elevated in all 20 cases tested (range 908 to 138,000 IU/L). One dog had undifferentiated round cell neoplastic infiltration within the muscle at the time of inflammatory myopathy diagnosis. Five dogs historically had mast cell tumours and 21 dogs were not diagnosed with neoplasia prior, at the time of or after inflammatory myopathy diagnosis. Treatment included glucocorticoid monotherapy (n=12), cyclosporine monotherapy (n=1) or multiple immune-suppressive medications (n=14). Six dogs neurologically improved, 11 improved but relapsed while on treatment, seven did not improve. Eight dogs were euthanased, one died, four were lost to follow-up.
Boxer dogs with non-infectious inflammatory myopathy can present for generalised weakness and dysphagia; long-term successful outcome is uncommon. The relationship between neoplasia and non-infectious inflammatory myopathy in boxer dogs remains unclear; future prospective studies evaluating a larger cohort are warranted.
评估加利福尼亚大学圣地亚哥分校比较神经肌肉实验室 2010 年至 2018 年间经组织学诊断为非传染性炎性肌病的拳师犬的临床特征、治疗、结果及与恶性肿瘤的潜在关联。
本回顾性研究纳入了在加利福尼亚大学圣地亚哥分校比较神经肌肉实验室经组织学诊断为非传染性炎性肌病且病历完整的拳师犬。记录了犬的一般信息、病史、临床症状、临床病理发现、治疗和结果。
共纳入 28 只非传染性炎性肌病的拳师犬，年龄 1 至 11 岁，其中 18 只为雄性（16 只为去势；2 只为未去势），10 只为雌性（7 只为去势；3 只为未去势）。临床症状包括全身无力（17 只）、吞咽困难（11 只）和体重减轻（10 只）。20 只接受检测的犬的血清肌酸激酶活性均升高（范围 908 至 138000IU/L）。1 只犬在炎性肌病诊断时肌肉内存在未分化的圆形细胞肿瘤浸润。5 只犬曾患有肥大细胞瘤，21 只犬在炎性肌病诊断前、诊断时或诊断后均未诊断出肿瘤。治疗包括糖皮质激素单药治疗（12 只）、环孢素单药治疗（1 只）或多种免疫抑制药物治疗（14 只）。6 只犬神经功能改善，11 只犬治疗时改善但复发，7 只犬未改善。8 只犬安乐死，1 只犬死亡，4 只犬失访。
患非传染性炎性肌病的拳师犬可表现为全身无力和吞咽困难；长期成功的预后并不常见。拳师犬的肿瘤与非传染性炎性肌病之间的关系尚不清楚；需要进一步前瞻性研究评估更大的队列。
