Department of Otolaryngology Head, Neck and Maxillofacial Surgery, Tel Aviv Sourasky Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
Laryngoscope. 2021 Sep;131(9):E2583-E2591. doi: 10.1002/lary.29609. Epub 2021 May 18.
OBJECTIVES/HYPOTHESIS: To investigate the risk of residual tympanic membrane (TM) perforation after intratympanic (IT) steroidal treatment administered via transtympanic injection compared with trans-tympanostomy tube (TyT).
Case series, systematic review and meta analysis.
Data were retrieved from the medical files of an original cohort of all consecutive patients with sudden sensorineural hearing loss necessitating IT steroidal treatment in a tertiary medical center between January 1, 2016 and November 20, 2020. A systematic literature search of "MEDLINE" via "PubMed," "Embase," and "Web of Science" on comparable published cases was performed and meta-analysis was established.
Eighteen studies describing 818 ears were included in the quantitative meta-analysis in addition to a local cohort of 140 ears. The proportion of residual TM perforation was 1.11% and 1.14% (95% confidence interval: 0.01%-3.27% and 0.028%-2.38%) in the TyT and trans-tympanic groups, respectively, suggesting no significant difference in residual TM perforation risk between these techniques.
IT steroid therapy via trans-TyT is not associated with more residual perforations than IT steroid therapy via transtympanic injections.
NA Laryngoscope, 131:E2583-E2591, 2021.
目的/假设：研究经鼓室注射与经鼓膜切开术置管（TyT）给予鼓室内类固醇治疗后残余鼓膜（TM）穿孔的风险。
病例系列、系统评价和荟萃分析。
数据来自 2016 年 1 月 1 日至 2020 年 11 月 20 日期间，在一家三级医疗中心因突发性感觉神经性听力损失需要鼓室内类固醇治疗的所有连续患者的原始队列的医疗记录中检索。通过“PubMed”、“Embase”和“Web of Science”对“MEDLINE”进行了系统的文献检索，并进行了荟萃分析。
除了局部队列的 140 只耳朵外，定量荟萃分析还纳入了 18 项描述 818 只耳朵的研究。TyT 和经鼓室组残余 TM 穿孔的比例分别为 1.11%和 1.14%（95%置信区间：0.01%-3.27%和 0.028%-2.38%），提示两种技术的残余 TM 穿孔风险无显著差异。
与经鼓室注射给予鼓室内类固醇治疗相比，经 TyT 给予鼓室内类固醇治疗不会导致更多的残余穿孔。
无。
喉科学，131：E2583-E2591，2021。
