Division of Gastroenterology, Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA.
Division of Gastroenterology, Indiana University, Indianapolis, Indiana, USA.
Am J Gastroenterol. 2021 Jun 1;116(6):1124-1147. doi: 10.14309/ajg.0000000000001278.
Clostridioides difficile infection occurs when the bacterium produces toxin that causes diarrhea and inflammation of the colon. These guidelines indicate the preferred approach to the management of adults with C. difficile infection and represent the official practice recommendations of the American College of Gastroenterology. The scientific evidence for these guidelines was evaluated using the Grading of Recommendations Assessment, Development, and Evaluation process. In instances where the evidence was not appropriate for Grading of Recommendations Assessment, Development, and Evaluation but there was consensus of significant clinical merit, key concept statements were developed using expert consensus. These guidelines are meant to be broadly applicable and should be viewed as the preferred, but not the only, approach to clinical scenarios.
艰难梭菌感染是由细菌产生毒素引起的，该毒素会导致腹泻和结肠炎症。这些指南指出了治疗艰难梭菌感染成人患者的首选方法，代表了美国胃肠病学会的官方实践建议。使用推荐评估、制定和评估（Grading of Recommendations Assessment, Development, and Evaluation，GRADE）过程对这些指南的科学证据进行了评估。在证据不适合推荐评估、制定和评估（Grading of Recommendations Assessment, Development, and Evaluation，GRADE）的情况下，但存在具有重要临床意义的共识时，使用专家共识制定了关键概念陈述。这些指南旨在广泛适用，应被视为临床情况的首选方法，但不是唯一方法。
