van Essen E J, Bovill J G, Ploeger E J, Beerman H
Department of Anesthesiology, Westeinde Hospital, The Hague, The Netherlands.
Acta Anaesthesiol Belg. 1988;39(2):109-12.
The use of intrathecal clonidine, in combination with intrathecal morphine, for the treatment of a patient with intractable cancer pain is reported. The addition of clonidine overcame the problem of tolerance to the analgesic effects of morphine alone. The patient was maintained pain free for three months, without complications, until his death. At autopsy, no evidence of neurotoxicity associated with the prolonged intrathecal administration of clonidine and morphine was found.
据报道，鞘内注射可乐定联合鞘内注射吗啡用于治疗一名患有顽固性癌痛的患者。添加可乐定克服了单独使用吗啡镇痛效果产生耐受性的问题。该患者无痛维持了三个月，没有出现并发症，直至死亡。尸检时，未发现与长期鞘内注射可乐定和吗啡相关的神经毒性证据。
