Harvey Philip D, Kane John M
University of Miami Miller School of Medicine, Florida.
Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York.
J Clin Psychiatry. 2021 May 4;82(3):IC20018AH3C. doi: 10.4088/JCP.IC20018AH3C.
Schizophrenia is a severe, lifelong disorder that affects cognitive, behavioral, and emotional functioning. Many individuals living with schizophrenia experience numerous relapses and ongoing impairment. Adverse effects are a frequent reason for medication nonadherence among patients with schizophrenia, and nonadherence is the single biggest risk factor for relapse. This Academic Highlights addresses best practices for improving adherence and outcomes for people living with schizophrenia, including lessening the side effect burden and providing comprehensive, patient-centric care. Simplifying the medication regimen, using shared decision-making, and offering psychosocial interventions are strategies that may contribute to better outcomes.
精神分裂症是一种严重的、终身性的疾病，会影响认知、行为和情感功能。许多精神分裂症患者会经历多次复发和持续的功能损害。不良反应是精神分裂症患者不坚持服药的常见原因，而不坚持服药是复发的最大单一风险因素。本学术要点介绍了改善精神分裂症患者依从性和治疗效果的最佳实践，包括减轻副作用负担以及提供全面的、以患者为中心的护理。简化药物治疗方案、采用共同决策以及提供心理社会干预等策略可能有助于取得更好的治疗效果。
