University of Missouri School of Medicine, Columbia, Missouri, USA.
University of North Carolina School of Medicine, Carrboro, North Carolina, USA.
J Clin Psychiatry. 2019 Feb 19;80(1):al18010ah2c. doi: 10.4088/JCP.al18010ah2c.
Schizophrenia is a chronic disorder that can be effectively controlled but will likely require lifelong treatment. Unfortunately, most patients experience numerous relapses, ongoing symptoms, and impairment, often because of treatment interruptions. Continuous treatment is imperative to prevent relapse and the potentially devastating consequences that can follow a return of psychotic symptoms. Clinicians must better monitor a common cause of relapse, nonadherence, and offer strategies to improve adherence. Strategies can target the patient, the environment, or treatment. One treatment-related strategy is the use of long-acting injectable (LAI) antipsychotics, which have the potential to reduce relapse and rehospitalization for many patients with schizophrenia.
精神分裂症是一种慢性疾病，可以得到有效控制，但可能需要终身治疗。不幸的是，大多数患者会经历多次复发、持续存在的症状和功能损害，这通常是由于治疗中断。持续治疗对于预防复发和精神症状复发可能带来的灾难性后果至关重要。临床医生必须更好地监测导致复发的常见原因——不遵医嘱，并提供改善依从性的策略。策略可以针对患者、环境或治疗本身。一种与治疗相关的策略是使用长效注射（LAI）抗精神病药，它有可能减少许多精神分裂症患者的复发和住院。
