Troshina E A
Endocrinology Research Center.
Probl Endokrinol (Mosk). 2021 Apr 8;67(2):4-9. doi: 10.14341/probl12744.
The immune, endocrine and nervous systems are integrated due to the existence of reciprocal pathways for transmitting information about changes in their actual functional state. The main task of the brain is to receive, integrate and store information, and there is strong evidence that this also applies to information obtained through the body's immune responses. It has been proven that the production of cytokines in the brain can be caused not only by peripheral immune stimulation, but also by the nerve cells themselves, stimulated by certain neurosensory signals. Evolutionarily preserved antihomeostatic mechanisms characteristic of specific diseases are the subject of further research, the results of which may be very important for the development of therapeutic strategies that would prevent the undesirable combined effects of immune and neuroendocrine mediators.
由于存在用于传递有关其实际功能状态变化信息的相互通路，免疫系统、内分泌系统和神经系统相互整合。大脑的主要任务是接收、整合和存储信息，并且有充分证据表明这也适用于通过身体免疫反应获得的信息。已经证明，大脑中细胞因子的产生不仅可以由外周免疫刺激引起，也可以由某些神经感觉信号刺激的神经细胞自身引起。特定疾病所特有的进化保守的抗稳态机制是进一步研究的主题，其结果对于开发能够预防免疫和神经内分泌介质不良联合作用的治疗策略可能非常重要。
