Biomedical Engineering Programme, Faculty of Engineering, Chulalongkorn University, Bangkok 10330, Thailand; Chulalongkorn Centre of Excellence for Parkinson's Disease & Related Disorders, Department of Medicine, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok 10330, Thailand.
Chulalongkorn Centre of Excellence for Parkinson's Disease & Related Disorders, Department of Medicine, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok 10330, Thailand.
J Neurol Sci. 2021 Jul 15;426:117487. doi: 10.1016/j.jns.2021.117487. Epub 2021 May 12.
Speech impairments are very common in patients with Parkinson's disease (PD). However, knowledge of their objective characteristics and relationship to other motor symptoms amongst Asian PD patients is limited.
To identify objective vowel sound characteristics in Thai PD patients and correlate with disease severity, as determined by UPDRS and various sub-scores.
We evaluated 100 Thai PD patients, with a mean age of 66.56 years (±7.52) and HY of 2.7 (±1.08), and 101 age-matched controls. Phonatory evaluation, comprising of 15 objective parameters, was conducted using the Multi-Dimensional Voice Programme with a sustained /a/ phonation.
PD patients exhibited significantly higher values of all dimensions of the phonatory parameters evaluated compared to controls (All, p < 0.001) except for duration of sustained phonation, which was significantly shorter in PD patients. When early- and advanced-stage patients were compared, significantly different parameters were limited to frequency perturbation parameters (Jitt, p = 0.01; RAP, p = 0.013; PPQ, p = 0.01; sPPQ, p = 0.001; vF0, p = 0.011), and NHR (p = 0.028). Several significant and moderate correlations were observed between both STD and frequency perturbation parameters and UPDRS-III, bradykinesia sub-score, and gait and postural instability sub-score. Both vF0, and STD significantly correlated with UPDRS-III and sub-scores in advanced stage patients.
Our study provides objective evidence of phonatory dysfunction in Asian PD patients with certain characteristics correlated with advanced stage or different motor dysfunction. Sustained vowel phonation is a promising digital outcome for global phenotyping a large number of PD patients.
言语障碍在帕金森病（PD）患者中非常常见。然而，亚洲 PD 患者的客观特征及其与其他运动症状的关系知之甚少。
确定泰国 PD 患者的客观元音特征，并与 UPDRS 和各种子评分确定的疾病严重程度相关。
我们评估了 100 名泰国 PD 患者，平均年龄 66.56 岁（±7.52 岁）和 HY 为 2.7（±1.08），以及 101 名年龄匹配的对照组。使用多维度语音计划进行语音评估，包括 15 个客观参数，进行持续/a/发声。
与对照组相比，PD 患者表现出所有评估的发声参数维度的显著更高值（全部，p<0.001），除了持续发声的持续时间，PD 患者的持续时间明显更短。当比较早期和晚期患者时，显著不同的参数仅限于频率扰动参数（Jitt，p=0.01；RAP，p=0.013；PPQ，p=0.01；sPPQ，p=0.001；vF0，p=0.011）和 NHR（p=0.028）。在 STD 和频率扰动参数与 UPDRS-III、运动迟缓子评分、步态和姿势不稳子评分之间观察到几个显著和中度相关。vF0 和 STD 与晚期患者的 UPDRS-III 和子评分显著相关。
我们的研究为亚洲 PD 患者的发音功能障碍提供了客观证据，这些特征与晚期或不同的运动功能障碍有关。持续元音发声是对大量 PD 患者进行整体表型分析的有前途的数字结果。
