对来自小鼠胚胎的核糖体系统中鸟苷四磷酸合成的报道证据的质疑。
Questioning of reported evidence for guanosine tetraphosphate synthesis in a ribosome system from mouse embryos.
作者信息
Martini O, Irr J, Richter D
出版信息
Cell. 1977 Dec;12(4):1127-31. doi: 10.1016/0092-8674(77)90175-1.
PMID:340046
Abstract
In 1974, Irr, Kaulenas and Unsworth reported that ppGpp is synthesized by cytosolic ribosomes from mouse embryos and proposed a role for ppGpp in the process of differentiation. This proposal is being challenged because ribosomes of mouse embryos from various stages of development and of mouse embryoid bodies were completely inactive in ppGpp formation.
摘要
1974年，伊尔、考莱纳斯和昂斯沃思报告称，ppGpp是由小鼠胚胎的胞质核糖体合成的，并提出ppGpp在分化过程中发挥作用。这一观点正受到挑战，因为来自不同发育阶段的小鼠胚胎和小鼠胚状体的核糖体在ppGpp形成过程中完全没有活性。
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