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对来自小鼠胚胎的核糖体系统中鸟苷四磷酸合成的报道证据的质疑。

Questioning of reported evidence for guanosine tetraphosphate synthesis in a ribosome system from mouse embryos.

作者信息

Martini O, Irr J, Richter D

出版信息

Cell. 1977 Dec;12(4):1127-31. doi: 10.1016/0092-8674(77)90175-1.

DOI:10.1016/0092-8674(77)90175-1
PMID:340046
Abstract

In 1974, Irr, Kaulenas and Unsworth reported that ppGpp is synthesized by cytosolic ribosomes from mouse embryos and proposed a role for ppGpp in the process of differentiation. This proposal is being challenged because ribosomes of mouse embryos from various stages of development and of mouse embryoid bodies were completely inactive in ppGpp formation.

摘要

1974年，伊尔、考莱纳斯和昂斯沃思报告称，ppGpp是由小鼠胚胎的胞质核糖体合成的，并提出ppGpp在分化过程中发挥作用。这一观点正受到挑战，因为来自不同发育阶段的小鼠胚胎和小鼠胚状体的核糖体在ppGpp形成过程中完全没有活性。

相似文献

1
Questioning of reported evidence for guanosine tetraphosphate synthesis in a ribosome system from mouse embryos.对来自小鼠胚胎的核糖体系统中鸟苷四磷酸合成的报道证据的质疑。
Cell. 1977 Dec;12(4):1127-31. doi: 10.1016/0092-8674(77)90175-1.
2
Synthesis of pppGpp by ribosomes from an Escherichia coli spoT mutant and the metabolic relationship between pppGpp and ppGpp.来自大肠杆菌spoT突变体的核糖体对pppGpp的合成以及pppGpp与ppGpp之间的代谢关系。
Can J Biochem. 1977 Dec;55(12):1207-12. doi: 10.1139/o77-180.
3
Template-independent synthesis of guanosine tetra- and pentaphosphates on ribosomes.核糖体上鸟苷四磷酸和五磷酸的模板非依赖性合成。
FEBS Lett. 1983 Oct 3;162(1):39-42. doi: 10.1016/0014-5793(83)81044-8.
4
Synthesis of guanosine polyphosphates (pppGpp and ppGpp) and its regulation by aminoacyl-tRNA.鸟苷多磷酸（pppGpp和ppGpp）的合成及其受氨酰-tRNA的调控
J Biochem. 1977 Oct;82(4):947-53. doi: 10.1093/oxfordjournals.jbchem.a131798.
5
Role of the aminoacyl end of transfer RNA in the allosteric control of guanosine pentaphosphate synthesis by the stringent factor-ribosome complex of Escherichia coli.
Biochemistry. 1978 Jul 11;17(14):2761-8. doi: 10.1021/bi00607a010.
6
Eukaryotic ribosomal proteins stimulate Escherichia coli stringent factor to synthesize guanosine 5'-diphosphate, 3'-diphosphate (ppGpp) and guanosine 5'-triphosphate, 3'-diphosphate (ppGpp).真核生物核糖体蛋白刺激大肠杆菌严谨因子合成鸟苷5'-二磷酸-3'-二磷酸（ppGpp）和鸟苷5'-三磷酸-3'-二磷酸（pppGpp）。
Mol Gen Genet. 1978 Nov 9;166(3):291-7. doi: 10.1007/BF00267621.
7
Ribosomal synthesis of guanosine tetra- and pentaphosphate with mRNAs of different chain length.核糖体利用不同链长的信使核糖核酸合成四磷酸鸟苷和五磷酸鸟苷。
FEBS Lett. 1977 Nov 1;83(1):125-7. doi: 10.1016/0014-5793(77)80655-8.
8
Methylgroups of ribosomal protein L11 are not related to the synthesis of ppGpp.核糖体蛋白L11的甲基基团与鸟苷四磷酸（ppGpp）的合成无关。
Mol Gen Genet. 1979 Feb 26;170(2):187-9. doi: 10.1007/BF00337795.
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Altered specificity of synthesis of guanosine tetraphosphate (ppGpp) and pentaphosphate (ppGpp) by salt-washed ribosomes.经盐洗涤的核糖体合成鸟苷四磷酸（ppGpp）和鸟苷五磷酸（pppGpp）的特异性改变。
Biochem Biophys Res Commun. 1974 May 7;58(1):268-71. doi: 10.1016/0006-291x(74)90922-x.
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Mouse embryos fail to synthesize detectable quantities of guanosine 5'-diphosphate 3'-diphosphate.小鼠胚胎无法合成可检测量的鸟苷5'-二磷酸3'-二磷酸。
Dev Biol. 1977 Mar;56(1):200-5. doi: 10.1016/0012-1606(77)90163-4.

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A RelA-SpoT homolog (Cr-RSH) identified in Chlamydomonas reinhardtii generates stringent factor in vivo and localizes to chloroplasts in vitro.在莱茵衣藻中鉴定出的一种RelA-SpoT同源物（Cr-RSH）在体内产生严谨因子，并在体外定位于叶绿体。
Nucleic Acids Res. 2002 Nov 15;30(22):4985-92. doi: 10.1093/nar/gkf628.
3
The search for guanosine tetraphosphate (ppGpp) and other unusual nucleotides in eucaryotes.
真核生物中鸟苷四磷酸（ppGpp）及其他异常核苷酸的研究。
Microbiol Rev. 1979 Mar;43(1):27-41. doi: 10.1128/mr.43.1.27-41.1979.
4
The stimulation of Escherichia coli stringent factor-dependent synthesis of guanosine 3',5'-polyphosphate [(p)ppGpp] by rat liver ribosomal proteins.
Mol Gen Genet. 1979 Nov;176(3):375-7. doi: 10.1007/BF00333100.
5
Eukaryotic ribosomal proteins stimulate Escherichia coli stringent factor to synthesize guanosine 5'-diphosphate, 3'-diphosphate (ppGpp) and guanosine 5'-triphosphate, 3'-diphosphate (ppGpp).真核生物核糖体蛋白刺激大肠杆菌严谨因子合成鸟苷5'-二磷酸-3'-二磷酸（ppGpp）和鸟苷5'-三磷酸-3'-二磷酸（pppGpp）。
Mol Gen Genet. 1978 Nov 9;166(3):291-7. doi: 10.1007/BF00267621.