Department of Anesthesiology, Columbia University College of Physicians and Surgeons, NY, New York, USA.
Department of Anesthesiology, New York-Presbyterian, Columbia University Medical Center, 622 W 168th St, NY, 10032, New York, USA.
BMC Anesthesiol. 2021 May 18;21(1):151. doi: 10.1186/s12871-021-01364-z.
Anesthetic management of an adult with failing Fontan physiology is complicated given inherent anatomical and physiological alterations. Neurosurgical interventions including thromboembolectomy may be particularly challenging given importance of blood pressure control and cerebral perfusion.
We describe a 29 year old patient born with double outlet right ventricle (DORV) with mitral valve atresia who after multi-staged surgeries earlier in life, presented with failing Fontan physiology. She was admitted to the hospital almost 29 years after her initial surgeries to undergo workup for a dual heart and liver transplant in the context of a failing Fontan with elevated end diastolic pressures, NYHA III heart failure symptoms, and liver cirrhosis from congestive hepatopathy. During the workup in the context of holding anticoagulation for invasive procedures, she developed a middle cerebral artery (MCA) stroke requiring a thromboembolectomy via left carotid artery approach. DISCUSSION AND CONCLUSIONS: This case posed many challenges to the anesthesiologist including airway control, hemodynamic and cardiopulmonary monitoring, evaluation of perfusion, vascular access, and management of anticoagulation in an adult patient in heart and liver failure with Fontan physiology undergoing thromboembolectomy for MCA embolic stroke.
由于解剖和生理改变的固有特性,患有 Fontan 生理衰竭的成人的麻醉管理变得复杂。神经外科干预,包括血栓切除术,由于血压控制和脑灌注的重要性,可能具有特别的挑战性。
我们描述了一位 29 岁的患者,出生时患有右心室双出口(DORV)伴二尖瓣闭锁,在早年接受了多次手术治疗后,出现了 Fontan 生理衰竭。她在最初手术后近 29 年因 Fontan 衰竭、舒张末期压力升高、NYHA III 心力衰竭症状和充血性肝病原发性充血性肝病变导致的肝硬化而入院,接受双心和肝移植的评估。在为侵入性操作进行抗凝治疗的同时,她发生了大脑中动脉(MCA)中风,需要通过左颈动脉入路进行血栓切除术。
该病例给麻醉师带来了许多挑战,包括气道控制、血流动力学和心肺监测、灌注评估、血管通路以及在患有 Fontan 生理衰竭、心脏和肝脏衰竭、正在接受 MCA 栓塞性中风血栓切除术的成年患者中抗凝管理。