Instituto Universitario de Oftalmobiología Aplicada (IOBA), Universidad de Valladolid, Valladolid, Spain; Departamento de Física Teórica, Atómica y Óptica, Universidad de Valladolid, Valladolid, Spain.
Instituto Universitario de Oftalmobiología Aplicada (IOBA), Universidad de Valladolid, Valladolid, Spain.
Cont Lens Anterior Eye. 2021 Dec;44(6):101467. doi: 10.1016/j.clae.2021.101467. Epub 2021 May 15.
To evaluate the usefulness of a global rate of change scale (GRCS) to detect variations in contact lens discomfort (CLD).
Symptomatic contact lens (CL) wearers were recruited according to the 'Contact Lens Dry Eye Questionnaire-8' (CLDEQ-8). At the baseline visit, subjects scored their comfort following insertion of their habitual CL using a 0-100 visual analogue scale (VAS). After 4-10 h of CL wear, comfort was again self-evaluated with the VAS and with a GRCS (range, -50 to +50). Then, a daily disposable CL (DDCL) was fitted. After one month of DDCL wear, a follow-up visit was conducted where the same evaluations as the baseline visit were performed. Changes in comfort were estimated using a Student's t-test for normal variables and the Friedman test for multiple comparisons of non-parametric variables. Internal responsiveness was measured by calculating the standardised response mean. Agreement between scales was estimated by the intraclass correlation coefficient (ICC).
Twenty-nine (22 females and 7 males) CL wearers with a mean age of 23.4 ± 5.4 years participated in the study. There was a significant decrease in comfort at both visits detected by the GRCS (baseline = -13.58 ± 17.48, p < 0.001; follow up = -6.86 ± 12.69, p = 0.007). However, the VAS did not detect that change, either at baseline (insertion = 64.28 ± 18.72 vs removal = 52.89 ± 17.64, p = 1.000) or follow-up visit (insertion = 81.97 ± 12.91 vs removal = 76.48 ± 16.02, p = 1.000). Comfort at insertion and removal times was significantly higher with the DDCL (p = 0.008 at insertion and p = 0.004 at removal). The standardised response mean was greater with the GRCS than the VAS at baseline (0.78 vs 0.63) and follow-up (0.54 vs 0.37) visits. Agreement between both scales was moderate and significant (p < 0.001) for both visits, ICC: 0.674 (95 % confidence interval (CI):0.411-0.833) (baseline) and 0.652 (95 % CI:0.377-0.821) (follow-up visit).
The GRCS can detect slight changes in CL wear comfort and shows higher responsiveness than the VAS. This subjective scale can allow detection of changes in comfort in a simple and quick way.
评估全球变化率量表（GRCS）在检测隐形眼镜不适（CLD）变化方面的有效性。
根据“隐形眼镜干眼症问卷-8”（CLDEQ-8），招募有症状的隐形眼镜（CL）佩戴者。在基线访视时，佩戴者在插入习惯的 CL 后，使用 0-100 视觉模拟量表（VAS）对舒适度进行自我评分。在 CL 佩戴 4-10 小时后，再次使用 VAS 和 GRCS（范围为-50 至+50）进行自我评估。然后，适配一次性日抛隐形眼镜（DDCL）。在佩戴 DDCL 一个月后，进行随访，进行与基线访视相同的评估。使用学生 t 检验评估正常变量的舒适度变化，使用 Friedman 检验评估非参数变量的多次比较。通过计算标准化反应均值来测量内部反应性。通过计算组内相关系数（ICC）来估计量表之间的一致性。
共有 29 名（22 名女性和 7 名男性）CL 佩戴者参与了研究，平均年龄为 23.4±5.4 岁。GRCS 检测到两次访视时舒适度均显著下降（基线=-13.58±17.48，p<0.001；随访=-6.86±12.69，p=0.007）。然而，VAS 无论是在基线（插入=64.28±18.72 与移除=52.89±17.64，p=1.000）还是随访（插入=81.97±12.91 与移除=76.48±16.02，p=1.000）时，均未检测到这种变化。在插入和移除时，DDCL 的舒适度明显更高（p=0.008 时插入，p=0.004 时移除）。在基线（0.78 比 0.63）和随访（0.54 比 0.37）时，GRCS 的标准化反应均值均大于 VAS。两种量表在两次访视时的一致性均为中度且显著（p<0.001），ICC：0.674（95%置信区间（CI）：0.411-0.833）（基线）和 0.652（95%CI：0.377-0.821）（随访）。
GRCS 可检测隐形眼镜佩戴舒适度的轻微变化，其反应性高于 VAS。这种主观量表可以简单快速地检测舒适度的变化。
