Kennedy R H, Brubaker R F
Department of Ophthalmology, Mayo Clinic.
Am J Ophthalmol. 1988 Aug 15;106(2):123-30. doi: 10.1016/0002-9394(88)90822-7.
From 1960 through 1984, traumatic hyphema was diagnosed in 248 residents (204 males and 44 females) of Olmsted County, Minnesota. The mean annual incidence rate was significantly greater (P less than .001) among males than among females: 20.2 per 100,000 population and 4.1 per 100,000, respectively. The overall mean annual rate was 12.2. A significant increase in the incidence rate in recent years was caused primarily by an increase in the number of sports-related injuries. Secondary hemorrhage occurred in 18 patients (7.3%) and was significantly (P less than .05) more frequent among patients whose initial hyphema filled more than one third of the anterior chamber. The low risk of secondary hemorrhage and associated serious sequelae suggests that the possible benefits from routine systemic administration of aminocaproic acid may not outweigh the costs and risks in populations similar to that of Olmsted County.
1960年至1984年期间，明尼苏达州奥尔姆斯特德县的248名居民（204名男性和44名女性）被诊断为外伤性前房积血。男性的年平均发病率显著高于女性（P <.001）：分别为每10万人中20.2例和4.1例。总体年平均发病率为12.2。近年来发病率的显著上升主要是由于与运动相关的损伤数量增加所致。18例患者（7.3%）发生了继发性出血，初始前房积血超过前房三分之一的患者中继发性出血明显更频繁（P <.05）。继发性出血及相关严重后遗症的低风险表明，在与奥尔姆斯特德县类似的人群中，常规全身应用氨基己酸的潜在益处可能无法超过成本和风险。
