Phinney R B, Mondino B J, Hofbauer J D, Meisler D M, Langston R H, Forstot S L, Benes S C
Stein Eye Institute, Department of Ophthalmology, UCLA School of Medicine 90024-1771.
Am J Ophthalmol. 1988 Aug 15;106(2):210-5. doi: 10.1016/0002-9394(88)90837-9.
Five patients developed corneal edema presumably caused by accidental preoperative ocular exposure to Hibiclens. In all cases, the patients complained of ocular pain after surgery. Conjunctival inflammation and corneal epithelial defects were found in all patients. Between two and ten weeks after exposure, stromal and epithelial edema, with a predilection for the inferior cornea initially, developed in all patients. The corneal edema resolved in three patients in approximately six months, leaving mild stromal scarring and reduced endothelial cell counts. The corneal edema in the other two patients progressed to diffuse bullous keratopathy, which eventually required penetrating keratoplasty. We recommend that Hibiclens be avoided in preoperative preparation of the facial skin to prevent accidental ocular exposure.
五名患者出现角膜水肿，推测是术前眼部意外接触洗必泰所致。所有病例中，患者术后均主诉眼痛。所有患者均发现结膜炎症和角膜上皮缺损。接触洗必泰后两至十周，所有患者均出现基质和上皮水肿，最初以下方角膜最为明显。三名患者的角膜水肿在约六个月内消退，遗留轻度基质瘢痕和内皮细胞计数减少。另外两名患者的角膜水肿进展为弥漫性大疱性角膜病变，最终需要进行穿透性角膜移植术。我们建议在面部皮肤术前准备中避免使用洗必泰，以防止眼部意外接触。
