Hernández-Castro Flavio, Berlanga-Garza Anaís, Cruz-Gutiérrez Mayela Diamantina, Soria-López Juan Antonio, Villagómez-Martínez Gabriel Edgar, Dávila-Escamilla Iván Vladimir
Universidad Autónoma de Nuevo León (UANL). Hospital Universitario Dr. José Eleuterio González. Departamento de Obstetricia y Medicina Materno Fetal. Monterrey, Nuevo León, México.
Rev Saude Publica. 2021 May 17;55:30. doi: 10.11606/s1518-8787.2021055002543. eCollection 2021.
Determine the value of the combination of fasting glucose less than the 10th percentile (FG < p10) during 75 gram oral glucose tolerance test (75g OGTT) with maternal characteristics to predict low birth weight (LBW) established by Intergrowth-21st tables.
Prospective cohort study of pregnant women who was underwent 75g OGTT between 24 and 28.6 weeks. The 10th percentile fasting glucose of the population was determined at 65 mg/dL and women with risk factors that could modify fetal weight, including those related to intrauterine growth restriction, were excluded. Two groups were formed: group FG < p10 and group with normal fasting glucose. The main finding was the diagnosis of LBW. The association between FG < p10, maternal characteristics and LBW was established by multivariate logistic regression. The predictive performance of the models constructed was evaluated by receiver operating characteristic (ROC) curve and area under the curve (AUC) analysis.
349 women were eligible for study, of whom 66 (18.91%) had FG < p10; neonates in this group had lower birth weights (2947.28 g and 3138.26 g, p = 0.001), higher frequencies of LBW (25% and 6.81%, p < 0.001) and of weights < 2500 g in term births (8.6% and 2.3%, p = 0.034). The basal prediction model consisted of nulliparity by achieving an AUC of 60%, while the addition of FG < p10 resulted in the significant improvement of the previous model (AUC 72%, DeLong: p = 0.005).
In pregnant women without factors that could modify fetal weight, the predictive model created by combining FG < p10 during 75g OGTT with nulliparity was significantly associated with increased risk of LBW.
ClinicalTrials.gov: NCT04144595.
确定在75克口服葡萄糖耐量试验（75g OGTT）期间空腹血糖低于第10百分位数（FG < p10）与孕妇特征相结合，以预测由Intergrowth-21st表格确定的低出生体重（LBW）的价值。
对在24至28.6周期间接受75g OGTT的孕妇进行前瞻性队列研究。该人群的第10百分位数空腹血糖确定为65mg/dL，排除有可改变胎儿体重的危险因素的妇女，包括与宫内生长受限相关的因素。形成两组：FG < p10组和空腹血糖正常组。主要观察指标是LBW的诊断。通过多因素逻辑回归确定FG < p10、孕妇特征与LBW之间的关联。通过受试者工作特征（ROC）曲线和曲线下面积（AUC）分析评估所构建模型的预测性能。
349名妇女符合研究条件，其中66名（18.91%）FG < p10；该组新生儿出生体重较低（2947.28克和3138.26克，p = 0.001），LBW发生率较高（25%和6.81%，p < 0.001），足月出生体重<2500克的频率较高（8.6%和2.3%，p = 0.034）。基础预测模型由初产情况组成，AUC为60%，而添加FG < p10导致先前模型有显著改善（AUC 72%，DeLong检验：p = 0.005）。
在没有可改变胎儿体重因素的孕妇中，75g OGTT期间FG < p10与初产情况相结合创建的预测模型与LBW风险增加显著相关。
ClinicalTrials.gov：NCT04144595。
