[氯霉素在兔体内的药代动力学研究]
[Pharmacokinetic study of chloramphenicol in the rabbit].
作者信息
Guillot P, Sanders P, Mourot D
机构信息
Ministère de l'Agriculture, Laboratoire National des Médicaments Vétérinaires.
出版信息
Ann Rech Vet. 1988;19(1):27-33.
PMID:3400970
Abstract
Chloramphenicol was administered intravenously and orally at a dose of 50 mg/kg to ten rabbits. Pharmacokinetic parameters were calculated (rate constant of terminal phase: beta = 0.21 +/- 0.09 1/h, total body clearance: Cl = 22.7 +/- 2.1 ml/min.kg, bioavailability: F = 42.5 +/- 11.9%) and were used to discuss the proposed dosage. However, caecotrophy might occur and increase absorption of chloramphenicol.
摘要
给十只兔子静脉注射和口服氯霉素，剂量为50毫克/千克。计算了药代动力学参数（终末相速率常数：β = 0.21 ± 0.09 1/小时，全身清除率：Cl = 22.7 ± 2.1毫升/分钟·千克，生物利用度：F = 42.5 ± 11.9%），并用于讨论建议的剂量。然而，可能会发生食粪行为并增加氯霉素的吸收。
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