Dale G, McGill A C, Seviour J A, Craft A W
Department of Clinical Biochemistry, Newcastle General Hospital, Newcastle upon Tyne, UK.
Ann Clin Biochem. 1988 May;25 ( Pt 3):233-6. doi: 10.1177/000456328802500306.
Gas chromatography with flame ionisation detection has been used to establish the normal urinary excretion values of homovanillic acid and 4-hydroxy-3-methoxymandelic acid in 808 infants aged 6 months. This study, the essential pre-requisite for population screening for neuroblastoma in babies, reveals a mean homovanillic acid of 10.9 mumol/mmol creatinine and mean 4-hydroxy-3-methoxymandelic of 6.8 mumol/mmol creatinine. The upper 95% confidence interval were 25.5 mumol/mmol creatinine for homovanillic acid and 15.0 mumol/mmol creatinine for 4-hydroxy-3-methoxymandelic. Gas chromatography/mass spectrometry analysis of the 39 samples, (4.8%) with apparent increased excretion of one or both metabolites, revealed that this was, in each case, due to interfering peaks on chromatography.
采用带有火焰离子化检测的气相色谱法，测定了808名6个月大婴儿尿中高香草酸和4-羟基-3-甲氧基扁桃酸的正常排泄值。这项研究是对婴儿进行神经母细胞瘤群体筛查的必要前提，结果显示高香草酸的平均排泄值为10.9 μmol/mmol肌酐，4-羟基-3-甲氧基扁桃酸的平均排泄值为6.8 μmol/mmol肌酐。高香草酸的95%置信区间上限为25.5 μmol/mmol肌酐，4-羟基-3-甲氧基扁桃酸的为15.0 μmol/mmol肌酐。对39份（4.8%）一种或两种代谢物排泄量明显增加的样本进行气相色谱/质谱分析，结果表明，每种情况均是由色谱图上的干扰峰所致。
