Ashby J P, Thakkar H
Department of Clinical Chemistry, Northwick Park Hospital, Harrow, Middlesex, UK.
Ann Clin Biochem. 1988 May;25 ( Pt 3):275-9. doi: 10.1177/000456328802500315.
Assays for N-terminus, C-terminus and mid-molecule parathyroid hormone have been assessed with respect to their sensitivity and specificity in the diagnosis of primary hyperparathyroidism (1 degree HPT). The mid-molecule assay was the most sensitive method studied and only failed to identify one out of 30 patients with histologically proven 1 degree HPT. In all three assays there was some degree of overlap between results observed in 1 degree HPT and in patients with non-parathyroid hypercalcaemia, with results in the latter group sometimes falling well within the hyperparathyroid range. This study highlights the limitations of currently available methods and emphasises the need for caution in the interpretation of parathyroid hormone (PTH) measurements.
针对N端、C端和中分子甲状旁腺激素检测在原发性甲状旁腺功能亢进症（1°HPT）诊断中的敏感性和特异性进行了评估。中分子检测是所研究的最敏感方法，在30例经组织学证实为1°HPT的患者中仅漏诊1例。在所有这三种检测中，1°HPT患者与非甲状旁腺性高钙血症患者的检测结果存在一定程度的重叠，后一组患者的结果有时完全落在甲状旁腺功能亢进范围内。本研究凸显了现有方法的局限性，并强调在解读甲状旁腺激素（PTH）测量结果时需谨慎。
