Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University.
Shaanxi Provincial Research Center for the Project of Prevention and Treatment of Respiratory Diseases, Xi'an, China.
Eur J Cancer Prev. 2022 May 1;31(3):253-259. doi: 10.1097/CEJ.0000000000000687.
To explore the lung cancer burden and related risk factors in groups of different sex, ages and levels of sociodemographic index (SDI) at global, regional and national levels.
Using newly released GBD 2019 data, we explored the trends of lung cancer burden and its related risk factors in groups of different sex, ages and levels of SDI at global, regional and national levels. The Global Health Data Exchange query tool was used to obtain the data.
While lung cancer has an overall stable age-standardized incidence rate (ASIR), the death rate (ASDR) and disability-adjusted life-years (DALYs) rate (with even a trend of decline), it is still the number one malignant tumor. The ASIR and ASDR grew slowly in women worldwide. In 2019, High-income North America, East Asia and Central Europe ranked top three in ASIR, ASDR and age-standardized DALY rate, with growth in East Asia the highest. These three indicators were not in a single linear relation with SDI at a national level, and a peak appeared when SDI was about 0.8. The top three attributable risk factors to DALYs were smoking, particulate matter pollution and occupational carcinogens.
Given the high heterogeneity in lung cancer burden among different populations, decision-makers should understand local epidemiological characteristics of lung cancer in detail to formulate effective policies. Stricter tobacco control and improvement in lung cancer screening and treatment are imperative.
在全球、地区和国家各级，探讨不同性别、年龄和社会人口学指数（SDI）水平组的肺癌负担及其相关危险因素。
利用新发布的 GBD 2019 数据，探讨了全球、地区和国家各级不同性别、年龄和 SDI 水平组的肺癌负担及其相关危险因素的变化趋势。使用全球卫生数据交换查询工具获取数据。
尽管肺癌的年龄标准化发病率（ASIR）、死亡率（ASDR）和伤残调整生命年（DALYs）率（甚至呈下降趋势）总体保持稳定，但它仍然是头号恶性肿瘤。全球范围内，女性肺癌的 ASIR 和 ASDR 增长缓慢。2019 年，高收入北美、东亚和中欧在 ASIR、ASDR 和年龄标准化 DALY 率方面排名前三，东亚的增长幅度最高。这些三个指标与国家一级的 SDI 并非呈单一的线性关系，在 SDI 约为 0.8 时出现峰值。导致 DALYs 的前三大风险因素是吸烟、颗粒物污染和职业性致癌物质。
鉴于不同人群的肺癌负担存在高度异质性，决策者应详细了解当地肺癌的流行病学特征，以制定有效的政策。严格的控烟措施以及改善肺癌筛查和治疗至关重要。
