Deutsches Rheuma-Forschungszentrum Berlin, a Leibniz Institute, Berlin, Germany.
Institute of Biotechnology, Technische Universität Berlin, Berlin, Germany.
Eur J Immunol. 2021 Jul;51(7):1592-1601. doi: 10.1002/eji.202049012. Epub 2021 Jun 1.
The adaptive immune system has the important ability to generate and maintain a memory for antigens once encountered. Recent progress in understanding the organization of immunological memory has challenged the established paradigm of maintenance of memory by restless, circulating, and "homeostatically" proliferating lymphocytes. Among other tissues, the bone marrow has emerged as a preferred resting place for memory lymphocytes providing both local and systemic long-term protection. Why the bone marrow? There, mesenchymal stromal cells provide a privileged environment for quiescent memory B and T lymphocytes, the protagonists of secondary immune reactions, and for memory plasma cells providing persistent humoral immunity. In this review, we discuss the dedicated role of the bone marrow for the maintenance of memory lymphocytes and its implications for immunological memory.
适应性免疫系统具有生成和维持对曾经遇到过的抗原的记忆的重要能力。最近在理解免疫记忆组织方面的进展挑战了通过不安定、循环和“稳态”增殖的淋巴细胞来维持记忆的既定模式。除其他组织外，骨髓已成为记忆淋巴细胞的首选休息场所，为局部和全身提供长期保护。为什么是骨髓？在那里，间充质基质细胞为静止的记忆 B 和 T 淋巴细胞（二次免疫反应的主角）以及提供持续体液免疫的记忆浆细胞提供了一个有利的环境。在这篇综述中，我们讨论了骨髓在维持记忆淋巴细胞中的专门作用及其对免疫记忆的影响。
