Department of Clinical Laboratory, Renmin Hospital of Wuhan University, China.
Department of Orthopedics, Renmin Hospital of Wuhan University, China.
J Psychosom Res. 2021 Jul;146:110506. doi: 10.1016/j.jpsychores.2021.110506. Epub 2021 May 3.
The effect of Fear of Falling (FOF) and fear-related Activity Restriction (AR) on Late Life Depression (LLD) remains unstudied in older adults. In this study, we aimed to clarify associations between FOF, AR and the prevalence and incidence of LLD in a large cohort of community-dwelling older adults.
In this prospective study, participants (n = 4230; 52.1% female) aged ≥50 years completed the survey on whether they had FOF and AR at baseline. In addition, the Centre for Epidemiological Studies Depression (CESD) scale was used to evaluate LLD at baseline and after 2 years of follow-up. Moreover, LLD was defined by a CES-D score ≥ 16, at follow-up.
The results showed that the prevalence and incidence of LLD were 6.9% (n = 293) and 4.2% (n = 167), respectively. In addition, most of the respondents with LLD were female (64.9% vs 55.4%) and 50-59 years of age (50.9% vs 42.8%, all P < 0.05). Analysis of data from Wave 1 and 2 using logistic regression also demonstrated that the levels of FOF/AR was associated with 82.2% and 62.7% higher odds of prevalence [OR = 1.822, 95%CI: 1.272-2.612] and incidence [OR = 1.627, 95%CI: 1.085-2.440] of LLD, respectively in the fully adjusted models.
FOF and AR may be associated with the prevalence and incidence of LLD. Additionally, the study highlighted the importance of assessing LLD in older adults with FOF and AR.
在老年人中，对跌倒恐惧（FOF）和与恐惧相关的活动限制（AR）对晚年抑郁症（LLD）的影响仍未得到研究。在这项研究中，我们旨在澄清在一大群社区居住的老年人中，FOF、AR 与 LLD 的患病率和发生率之间的关联。
在这项前瞻性研究中，参与者（n=4230；52.1%为女性）年龄≥50 岁，在基线时完成了关于他们是否有 FOF 和 AR 的调查。此外，使用中心流行病学研究抑郁量表（CESD）在基线和 2 年随访时评估 LLD。此外，在随访时，用 CES-D 评分≥16 来定义 LLD。
结果显示，LLD 的患病率和发生率分别为 6.9%（n=293）和 4.2%（n=167）。此外，大多数患有 LLD 的受访者为女性（64.9%比 55.4%）和 50-59 岁（50.9%比 42.8%，均 P<0.05）。使用逻辑回归对波 1 和 2 的数据分析也表明，FOF/AR 的水平与患病率[OR=1.822，95%CI：1.272-2.612]和发病率[OR=1.627，95%CI：1.085-2.440]分别高出 82.2%和 62.7%，这在完全调整的模型中。
FOF 和 AR 可能与 LLD 的患病率和发病率有关。此外，该研究强调了在有 FOF 和 AR 的老年人中评估 LLD 的重要性。
