Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, China.
Innovation Center for Cancer Research, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, No. 420, Fuma Road, Jinan District, 350014, Fuzhou, China.
BMC Geriatr. 2022 Nov 8;22(1):844. doi: 10.1186/s12877-022-03484-8.
Although studies have shown that depressive symptoms are associated with an increased risk of hip fracture (HF). Depressive symptoms are dynamic, and it is unclear whether HF risk persists if depressive symptoms remit. This study aims to examine the associations between changes in depressive symptoms and HF risk.
Data were from the China Health and Retirement Longitudinal Study from 2011 to 2018. Depressive symptoms were measured using the 10-item version of the Center for Epidemiological Studied Depression scale (cutoff ≥ 10). Changes in depressive symptoms were classified into four groups by two successive surveys (stable low/no, recent-onset, recently remitted, and stable high depressive symptoms). Multivariable logistic regressions were performed to assess whether changes in depressive symptoms were associated with HF incidents reported through 2018, adjusting for age, sex, educational level, marital status and other potential confounding factors.
In total, 8574 participants were included, 265 (3.1%) of whom had reported HF incidents in the subsequent 5-year period. Participants with recent-onset (OR = 1.97, 95% CI = 1.40-2.77) or stable high (OR = 2.15, 95% CI = 1.53-3.02) symptoms had a higher risk of HF than those with stable low/no depressive symptoms, whereas those with improved depressive symptoms (OR = 1.27, 95% CI = 0.89-1.82) had no elevation in HF risk.
Stable high and recent-onset depressive symptoms were associated with increased HF risk, and no elevated HF risk was observed if symptoms remitted, suggesting that strategies to reduce depressive symptoms may be beneficial for HF prevention.
尽管研究表明抑郁症状与髋部骨折（HF）风险增加有关。抑郁症状是动态的，如果抑郁症状缓解，HF 风险是否持续尚不清楚。本研究旨在探讨抑郁症状变化与 HF 风险之间的关系。
数据来自 2011 年至 2018 年的中国健康与退休纵向研究。使用流行病学研究抑郁量表的 10 项版本（临界值≥10）来衡量抑郁症状。通过两次连续调查，将抑郁症状的变化分为四组（稳定低/无、新发、近期缓解和稳定高抑郁症状）。多变量逻辑回归用于评估抑郁症状的变化是否与 2018 年报告的 HF 事件相关，调整年龄、性别、教育水平、婚姻状况和其他潜在混杂因素。
共纳入 8574 名参与者，其中 265 名（3.1%）在随后的 5 年内报告了 HF 事件。新发（OR=1.97，95%CI=1.40-2.77）或稳定高（OR=2.15，95%CI=1.53-3.02）症状的参与者发生 HF 的风险高于稳定低/无症状的参与者，而改善抑郁症状的参与者（OR=1.27，95%CI=0.89-1.82）HF 风险没有升高。
稳定高和新发的抑郁症状与 HF 风险增加相关，而症状缓解则没有升高的 HF 风险，表明减少抑郁症状的策略可能有利于 HF 预防。
