Department of Ophthalmology, Chang Gung Memorial Hospital, Chiayi.
Department of Pathology, Chang Gung Memorial Hospital, Chiayi.
Eur J Ophthalmol. 2022 Sep;32(5):NP55-NP59. doi: 10.1177/11206721211016303. Epub 2021 May 20.
Collision tumors are rare clinical entities that two heterogeneous neoplasms are concurrently adjacent to each other at the same location. The association of a squamous cell carcinoma and a malignant adnexal tumor is even infrequent.
The case of a 79-year-old woman having a slow-growing and painless tumor on the left lower eyelid was presented. The lesion, about 15 mm in diameter, was nodular, irregular, and yellow-discolored. Histopathologic and immunohistochemical findings disclosed concurrence of sebaceous carcinoma as well as squamous cell carcinoma in one specimen. Wide excision of the tumor with frozen section control and eyelid reconstruction were performed. Oncologic survey revealed no other lesion. At 6-month follow-up, no evidence of recurrence or metastasis was presented.
Collision tumor composed of sebaceous carcinoma and squamous cell carcinoma in eyelid may be the first case described in the literature. For increasing accuracy of diagnosis and management, a thorough clinical examination and detailed histopathologic analysis, along with multidisciplinary discussion, are prerequisites.
碰撞瘤是一种罕见的临床实体，两种异质性肿瘤同时在同一部位相邻。鳞状细胞癌和恶性附属器肿瘤的同时发生甚至更为罕见。
我们报告了一例 79 岁女性的病例，她的左眼左下眼睑有一个生长缓慢、无痛的肿瘤。病变约 15mm 直径，呈结节状、不规则状，呈黄色变色。组织病理学和免疫组织化学检查显示同一标本中同时存在皮脂腺癌和鳞状细胞癌。我们进行了肿瘤的广泛切除，并进行了冰冻切片控制和眼睑重建。肿瘤学检查未发现其他病变。在 6 个月的随访中，未发现复发或转移的证据。
由眼睑的皮脂腺癌和鳞状细胞癌组成的碰撞瘤可能是文献中首次描述的病例。为了提高诊断和治疗的准确性，彻底的临床检查和详细的组织病理学分析，以及多学科讨论是必要的。
