Van Johnson E, Kline L B, Julian B A, Garcia J H
Combined Program in Ophthalmology, Eye Foundation Hospital, Birmingham, AL.
Arch Ophthalmol. 1988 Aug;106(8):1089-92. doi: 10.1001/archopht.1988.01060140245034.
A 49-year-old man requiring hemodialysis for end-stage renal disease developed orbital cellulitis and bilateral central retinal artery occlusions. Although cranial computed tomography demonstrated ethmoid and sphenoid sinusitis, two surgical biopsy specimens of sinus mucosa were nondiagnostic. Autopsy findings confirmed cerebral mucormycosis with bilateral cavernous sinus and carotid artery thrombosis. The patient had been taking deferoxamine for hemochromatosis, and this chelating agent may have been the predisposing factor in developing mucormycosis. We discuss the limitations of current neuroimaging techniques in establishing the diagnosis of both cerebral mucormycosis and cavernous sinus thrombosis.
一名49岁因终末期肾病需要进行血液透析的男性患者发生了眼眶蜂窝织炎和双侧视网膜中央动脉阻塞。尽管头颅计算机断层扫描显示筛窦和蝶窦炎，但两份鼻窦黏膜手术活检标本均未明确诊断。尸检结果证实为脑部毛霉菌病伴双侧海绵窦和颈动脉血栓形成。该患者一直在服用去铁胺治疗血色素沉着症，这种螯合剂可能是发生毛霉菌病的诱发因素。我们讨论了当前神经影像学技术在诊断脑部毛霉菌病和海绵窦血栓形成方面的局限性。
