Faculty of Residency, Riga Stradins University, Riga, Latvia.
Paul Stradins Clinical University Hospital, Riga, Latvia.
BMJ Case Rep. 2021 May 19;14(5):e241449. doi: 10.1136/bcr-2020-241449.
Familial Mediterranean fever (FMF) is an autoinflammatory disease caused by a pyrin dysfunction, leading to uncontrolled interleukin-1 production that triggers the attacks. Here we report a case of a 36-year-old female patient repeatedly admitted to the cardiology ward with recurrent episodes of pericarditis, with intervals of 1 and 2 months between the episodes. During the attacks, chest pain and fever were the only symptoms. Following the administration of steroids and non-steroidal anti-inflammatory drugs, the patient became afebrile. She also had lymphoma and thyroid carcinoma in anamnesis essential for differential diagnosis. Laboratory tests for infection and autoimmune disease were all negative, and the positron emission tomography-CT scan did not reveal lymphoma relapse. Genetic testing revealed a mutation in the gene. It is very rare for pericarditis to be the first and only manifestation of FMF.
家族性地中海热（FMF）是一种由 pyrin 功能障碍引起的自身炎症性疾病，导致失控的白细胞介素-1 产生，从而引发发作。在这里，我们报告了一例 36 岁女性患者的病例，她因反复发作性心包炎反复入住心内科病房，两次发作之间的间隔为 1 个月和 2 个月。在发作期间，胸痛和发热是唯一的症状。在给予类固醇和非甾体抗炎药后，患者体温恢复正常。她既往还患有淋巴瘤和甲状腺癌，这对鉴别诊断很重要。感染和自身免疫性疾病的实验室检查均为阴性，正电子发射断层扫描-CT 扫描未显示淋巴瘤复发。基因检测显示基因发生突变。心包炎是 FMF 的首发和唯一表现极为罕见。
