Cornwell-Jones C A
Center for the Neurobiology of Learning and Memory, University of California, Irvine 92717.
Behav Neural Biol. 1988 Jul;50(1):1-15. doi: 10.1016/s0163-1047(88)90720-0.
Olfactory investigation was examined in male Sprague-Dawley rats injected with 50 mg/kg of the noradrenergic neurotoxin, DSP4, 10 days before testing. In a two-choice preference test, the odor of pine shavings from the nest of a female and her litter attracted sexually experienced control males, but not drug-treated males. Further, odors from anesthetized females increased the mean number of entries made by control males, but not drug-treated males, into a cage containing pups' nest shavings. Combining a novel odor with nest shavings significantly reduced the number of entries made by both groups of males. Drug treatment decreased norepinephrine (NE) levels by 66, 62, and 68% in the olfactory cortex, olfactory bulb, and frontal cortex, respectively. Dopamine concentrations were not significantly affected. NE concentrations in the heart, and serotonin levels in the olfactory bulb, were moderately depleted (by 37 and 40%, respectively). The results support the view that central NE modulates systems regulating attraction to conspecific odors in male rats.
在测试前10天，给雄性斯普拉格-道利大鼠注射50毫克/千克的去甲肾上腺素能神经毒素DSP4，然后对其嗅觉进行研究。在一项双选偏好测试中，来自雌性及其幼崽巢穴的松木刨花气味吸引了有性经验的对照雄性大鼠，但未吸引药物处理过的雄性大鼠。此外，麻醉雌性大鼠的气味增加了对照雄性大鼠进入装有幼崽巢穴刨花笼子的平均次数，但未增加药物处理过的雄性大鼠的次数。将一种新气味与巢穴刨花混合显著减少了两组雄性大鼠的进入次数。药物处理分别使嗅觉皮层、嗅球和额叶皮层中的去甲肾上腺素（NE）水平降低了66%、62%和68%。多巴胺浓度未受到显著影响。心脏中的NE浓度以及嗅球中的血清素水平中度降低（分别降低了37%和40%）。这些结果支持这样一种观点，即中枢NE调节雄性大鼠中调节对同种气味吸引力的系统。
