Cornwell-Jones C A, Bollers H R
Brain Res. 1983 Jun 6;268(2):291-4. doi: 10.1016/0006-8993(83)90495-x.
Odor-guided behavior was examined in male rats injected at birth and 48 h later with either the catecholaminergic neurotoxin 6-hydroxydopamine (60 micrograms/g, i.p.) or vehicle. In odor preference tests administered 8 or 74 days postnatally, drug-treated animals avoided novel odors which were neutral for controls and showed reduced preference for conspecific nest odors. In emergence tests administered 73-75 days postnatally, odors from an anesthetized female reduced approach latency and increased investigation of familiar conspecific odors for control but not drug-treated males. Neonatal drug treatment decreased adult olfactory cortex norepinephrine (NE) levels by 50%, but did not significantly influence either cardiac NE or olfactory cortex dopamine. The results imply that brain NE facilitates attraction to familiar conspecific odors.
对出生时及出生后48小时注射儿茶酚胺能神经毒素6-羟基多巴胺（60微克/克，腹腔注射）或赋形剂的雄性大鼠的气味引导行为进行了研究。在出生后8天或74天进行的气味偏好测试中，接受药物治疗的动物避开了对对照组来说无偏好的新气味，并且对同种巢穴气味的偏好降低。在出生后73 - 75天进行的出洞测试中，来自麻醉雌性的气味缩短了对照组雄性接近的潜伏期并增加了对熟悉的同种气味的探究，但对接受药物治疗的雄性没有影响。新生期药物治疗使成年嗅球去甲肾上腺素（NE）水平降低了50%，但对心脏NE或嗅球多巴胺均无显著影响。结果表明，脑内NE促进对熟悉的同种气味的吸引。
