Isaacson R L, Danks A M, Brakkee J, Schefman K, Gispen W H
Department of Psychology, University Center at Binghamton, New York 13901.
Behav Neural Biol. 1988 Jul;50(1):37-45. doi: 10.1016/s0163-1047(88)90756-x.
Previous studies have shown that peripheral injections of the codeinone RX 336-M can induce excessive grooming in rats in an age-dependent fashion. The present experiment demonstrates that codeine, itself, also induces excessive grooming but with apparent equal effectiveness at all ages tested. Because of the structural similarity between codeine and morphine, the effects of intraperitoneally administered morphine were examined as well. Morphine was found to produce a temporal course of excessive grooming quite different from that produced by codeine. Morphine did not affect grooming in the first half (30 min) of the observation period, but accentuated it, briefly, for the next 30-45 min. Intraventricular administration of codeine at doses of 0.3 or 1.0 microgram/3 microliter had no effect on grooming in animals previously shown to demonstrate excessive grooming in response to either dose.
先前的研究表明，向大鼠外周注射可待因酮RX 336 - M能以年龄依赖的方式诱发大鼠过度梳理毛发行为。本实验表明，可待因本身也会诱发过度梳理毛发行为，但在所有测试年龄组中效果明显相同。由于可待因与吗啡在结构上相似，因此也研究了腹腔注射吗啡的效果。结果发现，吗啡产生的过度梳理毛发行为的时间进程与可待因产生的截然不同。吗啡在观察期的前半段（30分钟）对梳理毛发行为没有影响，但在接下来的30 - 45分钟内会短暂加剧这种行为。向先前已显示对任一剂量都会表现出过度梳理毛发行为的动物脑室内注射0.3或1.0微克/3微升剂量的可待因，对其梳理毛发行为没有影响。
