Isaacson R L, Hardy C A, Hannigan J H
Behav Neural Biol. 1987 May;47(3):250-61. doi: 10.1016/s0163-1047(87)90383-9.
Peripheral administration of the dihydrocodeinone RX 336-M (6 mg/kg) stimulated vigorous "wet-dog" shakes and excessive grooming in young drug-naive rats. The effects of RX 336-M were greater in younger than in older animals of both sexes, and were greater in 39-day-old male rats than in female rats of the same age. In a second experiment, female rats were pretreated with testosterone benzoate (1 mg/kg/day) for 1 week prior to testing the effects of RX 336-M at 39 days of age. The sex hormone pretreatment enhanced the ability to RX 336-M to induce "wet-dog" shakes and excessive grooming in female rats. The results suggest that both sex- and hormone-dependent developmental status are critical in the display of the so-called "quasi-morphine withdrawal syndrome." The results imply, and are consistent with previous studies which suggest, that different neural mechanisms underlie the behavioral responses induced by ACTH and RX 336-M.
对未接触过药物的幼鼠经外周给予二氢可待因酮RX 336-M（6毫克/千克），会刺激其剧烈地“湿狗”式抖动并过度梳理毛发。RX 336-M对年轻动物的作用比对年长动物的作用更大，且在39日龄雄性大鼠中的作用比同龄雌性大鼠更大。在第二项实验中，在对39日龄的雌性大鼠测试RX 336-M的作用之前，先对其进行为期1周的苯甲酸睾酮（1毫克/千克/天）预处理。性激素预处理增强了RX 336-M在雌性大鼠中诱导“湿狗”式抖动和过度梳理毛发的能力。结果表明，性别和激素依赖的发育状态在所谓“类吗啡戒断综合征”的表现中都至关重要。结果意味着，并且与之前的研究一致，即促肾上腺皮质激素（ACTH）和RX 336-M诱导的行为反应背后存在不同的神经机制。
