Guzmán M, Geelen M J
Department of Biochemistry, Faculty of Chemistry, Complutense University, Madrid, Spain.
Biochem Biophys Res Commun. 1988 Jul 29;154(2):682-7. doi: 10.1016/0006-291x(88)90193-3.
Ethanol decreased the activity of carnitine palmitoyltransferase I and the rate of fatty acid oxidation in rat hepatocytes in short-term incubations. These effects were mimicked by acetaldehyde, the product of hepatic ethanol metabolism, and were absent when ethanol oxidation was prevented by 4-methylpyrazole. Ethanol was also able to increase intracellular malonyl-CoA levels. The results suggest that inhibition of fatty acid translocation into mitochondria may play an important role in the ethanol-induced inhibition of hepatic fatty acid oxidation.
在短期孵育中，乙醇降低了大鼠肝细胞中肉碱棕榈酰转移酶I的活性以及脂肪酸氧化速率。乙醛（肝脏乙醇代谢产物）可模拟这些效应，而当用4-甲基吡唑阻止乙醇氧化时，这些效应则不存在。乙醇还能够提高细胞内丙二酰辅酶A水平。结果表明，脂肪酸向线粒体转运的抑制可能在乙醇诱导的肝脏脂肪酸氧化抑制中起重要作用。
