[非那西汀的生物转化]
[The biotransformation of fenetylline].
作者信息
Rücker G, Neugebauer M, Heiden P G
机构信息
Pharmazeutischen Institut, Universität Bonn.
出版信息
Arzneimittelforschung. 1988 Apr;38(4):497-501.
PMID:3401264
Abstract
After oral administration of 3,7-dihydro-1,3-dimethyl-7-2 [(1-methyl-2-phenylethyl)-amino-ethyl]-1H-purine-2,6-dione (fenetylline, Captagon), 7 new metabolites could be detected in urine besides 4 known substances. The metabolites were identified by gas chromatography (GC) and by comparison of the mass spectra (MS) of metabolites with those of authentic reference compounds using a combined GC/MS method.
摘要
口服3,7-二氢-1,3-二甲基-7-[2-（1-甲基-2-苯乙基）氨基乙基]-1H-嘌呤-2,6-二酮（芬乙茶碱，卡西酮）后，除了4种已知物质外，还能在尿液中检测到7种新的代谢物。使用气相色谱-质谱联用（GC/MS）方法，通过气相色谱（GC）以及将代谢物的质谱（MS）与真实参考化合物的质谱进行比较，对这些代谢物进行了鉴定。
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