非小细胞肺癌的术前和术后放疗：仍是一个悬而未决的问题。
Preoperative and postoperative radiotherapy (RT) for non-small cell lung cancer: still an open question.
作者信息
Van Houtte Paul, Moretti Luigi, Charlier Florian, Roelandts Martine, Van Gestel Dirk
机构信息
Department of Radiation Oncology, Institut Jules Bordet, Université Libre Bruxelles, Brussels, Belgium.
出版信息
Transl Lung Cancer Res. 2021 Apr;10(4):1950-1959. doi: 10.21037/tlcr-20-472.
Abstract
Preoperative and postoperative radiotherapy (PORT) with or without chemotherapy has been used in non-small cell lung cancer (NSCLC) for decades. Numerous trials have investigated the potential survival benefit of this strategy, but despite greater knowledge of the disease, considerable technological developments in imaging and radiotherapy, and significant progress in surgery, many questions remain unsolved. In this review, we summarize the current knowledge on this problem and discuss issues which still require elucidation.
摘要
术前和术后放疗（PORT）联合或不联合化疗已在非小细胞肺癌（NSCLC）中应用了数十年。众多试验研究了该策略潜在的生存获益，但尽管对该疾病有了更多了解，成像和放疗技术有了显著发展，手术也取得了重大进展，许多问题仍未得到解决。在本综述中，我们总结了关于这一问题的现有知识，并讨论了仍需阐明的问题。
相似文献
1
Preoperative and postoperative radiotherapy (RT) for non-small cell lung cancer: still an open question.非小细胞肺癌的术前和术后放疗：仍是一个悬而未决的问题。
Transl Lung Cancer Res. 2021 Apr;10(4):1950-1959. doi: 10.21037/tlcr-20-472.
2
Sequencing postoperative radiotherapy and adjuvant chemotherapy in non-small cell lung cancer: unanswered questions on the not evidence-based approach.非小细胞肺癌术后放疗与辅助化疗的序贯：基于非循证方法的未决问题
J Thorac Dis. 2016 Jul;8(7):1381-5. doi: 10.21037/jtd.2016.05.76.
3
4
Does the addition of postoperative radiotherapy to adjuvant chemotherapy offer any benefit in patients with non-small cell lung cancer and mediastinal lymphadenopathy?
Interact Cardiovasc Thorac Surg. 2017 Apr 1;24(4):625-630. doi: 10.1093/icvts/ivw380.
5
6
Radiotherapy and chemotherapy in locally advanced non-small cell lung cancer: preclinical and early clinical data.局部晚期非小细胞肺癌的放疗与化疗：临床前及早期临床数据
Hematol Oncol Clin North Am. 2004 Feb;18(1):41-53. doi: 10.1016/s0889-8588(03)00138-2.
7
Role of adjuvant radiotherapy in completely resected non-small-cell lung cancer.辅助放疗在完全切除的非小细胞肺癌中的作用。
EJC Suppl. 2013 Sep;11(2):123-30. doi: 10.1016/j.ejcsup.2013.07.022.
8
The emerging outcome of postoperative radiotherapy for stage IIIA(N2) non-small cell lung cancer patients: based on the three-dimensional conformal radiotherapy technique and institutional standard clinical target volume.ⅢA期（N2）非小细胞肺癌患者术后放疗的新结局：基于三维适形放疗技术和机构标准临床靶区体积
BMC Cancer. 2015 May 2;15:348. doi: 10.1186/s12885-015-1326-6.
9
Postoperative radiotherapy for lung cancer: Is it worth the controversy?肺癌术后放疗：值得争议吗？
Cancer Treat Rev. 2016 Dec;51:10-18. doi: 10.1016/j.ctrv.2016.10.001. Epub 2016 Oct 14.
10
Modern post-operative radiotherapy for stage III non-small cell lung cancer may improve local control and survival: a meta-analysis.现代Ⅲ期非小细胞肺癌术后放疗可能改善局部控制率和生存率：一项荟萃分析。
Radiother Oncol. 2014 Jan;110(1):3-8. doi: 10.1016/j.radonc.2013.08.011. Epub 2013 Oct 4.
引用本文的文献
1
A Systematic Review of Short-Term Outcomes of Minimally Invasive Thoracoscopic Surgery for Lung Cancer after Neoadjuvant Systemic Therapy.新辅助全身治疗后肺癌微创胸腔镜手术短期疗效的系统评价
Cancers (Basel). 2023 Aug 1;15(15):3908. doi: 10.3390/cancers15153908.
2
The Clinical Characteristics and Treatments for Large Cell Carcinoma Patients Older than 65 Years Old: A Population-Based Study.65岁以上大细胞癌患者的临床特征与治疗：一项基于人群的研究。
Cancers (Basel). 2022 Oct 25;14(21):5231. doi: 10.3390/cancers14215231.
3
Role of Adjuvant Radiotherapy in Non-Small Cell Lung Cancer-A Review.辅助放疗在非小细胞肺癌中的作用——综述
Cancers (Basel). 2022 Mar 23;14(7):1617. doi: 10.3390/cancers14071617.
本文引用的文献
1
High-dose neoadjuvant chemoradiotherapy versus chemotherapy alone followed by surgery in potentially-resectable stage IIIA-N2 NSCLC. A multi-institutional retrospective study by the Oncologic Group for the Study of Lung Cancer (Spanish Radiation Oncology Society).高剂量新辅助放化疗与单纯化疗后手术治疗可切除的IIIA-N2期非小细胞肺癌的比较。一项由肺癌研究肿瘤学组（西班牙放射肿瘤学会）开展的多机构回顾性研究。
Rep Pract Oncol Radiother. 2020 May-Jun;25(3):447-455. doi: 10.1016/j.rpor.2020.03.006. Epub 2020 Mar 18.
2
Postoperative Radiotherapy for Resected Stage IIIA-N2 Non-small-cell Lung Cancer: A Population-Based Time-Trend Study.术后放疗治疗 IIIA-N2 期可切除非小细胞肺癌：一项基于人群的时间趋势研究。
Lung. 2019 Dec;197(6):741-751. doi: 10.1007/s00408-019-00284-7. Epub 2019 Nov 8.
3
The role of postoperative radiotherapy for completely resected pIIIA-N2 non-small cell lung cancer patients with different clinicopathological features: a systemic review and meta-analysis.术后放疗对具有不同临床病理特征的完全切除的IIIA-N2期非小细胞肺癌患者的作用：一项系统评价和荟萃分析。
J Cancer. 2019 Jun 24;10(17):3941-3949. doi: 10.7150/jca.28680. eCollection 2019.
4
The Dosimetric Comparisons of CRT, IMRT, ARC, CRT+IMRT, and CRT+ARC of Postoperative Radiotherapy in IIIA-N2 Stage Non-Small-Cell Lung Cancer Patients.术后放疗治疗 IIIA-N2 期非小细胞肺癌患者的 CRT、IMRT、ARC、CRT+IMRT 和 CRT+ARC 的剂量学比较。
Biomed Res Int. 2019 Mar 18;2019:8989241. doi: 10.1155/2019/8989241. eCollection 2019.
5
Preoperative radiation may improve the outcomes of resectable IIIA/N2 non-small-cell lung cancer patients: A propensity score matching-based analysis from surveillance, epidemiology, and end results database.术前放疗可能改善可切除 IIIA/N2 期非小细胞肺癌患者的预后：来自监测、流行病学和最终结果数据库的倾向评分匹配分析。
Cancer Med. 2018 Sep;7(9):4354-4360. doi: 10.1002/cam4.1701. Epub 2018 Jul 29.
6
Induction chemoradiotherapy versus chemotherapy alone for superior sulcus lung cancer.诱导放化疗对比单纯化疗用于肺上沟瘤。
Lung Cancer. 2018 Aug;122:206-213. doi: 10.1016/j.lungcan.2018.06.021. Epub 2018 Jun 19.
7
NCCN Guidelines Insights: Non-Small Cell Lung Cancer, Version 5.2018.NCCN 指南解读：非小细胞肺癌，第 5 版，2018 年。
J Natl Compr Canc Netw. 2018 Jul;16(7):807-821. doi: 10.6004/jnccn.2018.0062.
8
Postoperative Radiotherapy for Surgically Resected ypN2 Non-Small Cell Lung Cancer.手术切除的 ypN2 期非小细胞肺癌的术后放疗。
Ann Thorac Surg. 2018 Sep;106(3):848-855. doi: 10.1016/j.athoracsur.2018.04.064. Epub 2018 May 26.
9
Sequential Versus Concurrent Chemoradiation Therapy by Surgical Margin Status in Resected Non-Small Cell Lung Cancer.手术切缘状态对非小细胞肺癌根治术后序贯与同步放化疗的影响。
J Natl Compr Canc Netw. 2018 May;16(5):508-516. doi: 10.6004/jnccn.2018.7007.
10
ESTRO ACROP guidelines for target volume definition in the treatment of locally advanced non-small cell lung cancer.ESTRO ACROP 指南：局部晚期非小细胞肺癌治疗中的靶区定义。
Radiother Oncol. 2018 Apr;127(1):1-5. doi: 10.1016/j.radonc.2018.02.023. Epub 2018 Mar 28.
Zotero 插件