感染会诱导产生针对严重急性呼吸综合征冠状病毒2（SARS-CoV-2）刺突蛋白上碳水化合物表位的交叉反应性抗体。
infection induces cross-reactive antibodies to carbohydrate epitopes on the SARS-CoV-2 Spike protein.
作者信息
Lapidus Sarah, Liu Feimei, Casanovas-Massana Arnau, Dai Yile, Huck John D, Lucas Carolina, Klein Jon, Filler Renata B, Strine Madison S, Sy Mouhamad, Deme Awa B, Badiane Aida S, Dieye Baba, Ndiaye Ibrahima Mbaye, Diedhiou Younous, Mbaye Amadou Moctar, Diagne Cheikh Tidiane, Vigan-Womas Inés, Mbengue Alassane, Sadio Bacary D, Diagne Moussa M, Moore Adam J, Mangou Khadidiatou, Diallo Fatoumata, Sene Seynabou D, Pouye Mariama N, Faye Rokhaya, Diouf Babacar, Nery Nivison, Costa Federico, Reis Mitermayer, Muenker M Catherine, Hodson Daniel Z, Mbarga Yannick, Katz Ben Z, Andrews Jason R, Campbell Melissa, Srivathsan Ariktha, Kamath Kathy, Baum-Jones Elisabeth, Faye Ousmane, Sall Amadou Alpha, Quintero Vélez Juan Carlos, Cappello Michael, Wilson Michael, Ben-Mamoun Choukri, Somé Fabrice A, Dabiré Roch K, Moukoko Carole Else Eboumbou, Ouédraogo Jean Bosco, Boum Yap, Shon John, Ndiaye Daouda, Wisnewski Adam, Parikh Sunil, Iwasaki Akiko, Wilen Craig B, Ko Albert I, Ring Aaron M, Bei Amy K
机构信息
Yale School of Public Health, Department of Epidemiology of Microbial Diseases, New Haven, CT, 06510, USA.
Yale School of Medicine, Department of Immunobiology, New Haven, CT, 06510, USA.
出版信息
medRxiv. 2021 May 12:2021.05.10.21256855. doi: 10.1101/2021.05.10.21256855.
Individuals with acute malaria infection generated high levels of antibodies that cross-react with the SARS-CoV-2 Spike protein. Cross-reactive antibodies specifically recognized the sialic acid moiety on N-linked glycans of the Spike protein and do not neutralize SARS-CoV-2. Sero-surveillance is critical for monitoring and projecting disease burden and risk during the pandemic; however, routine use of Spike protein-based assays may overestimate SARS-CoV-2 exposure and population-level immunity in malaria-endemic countries.
急性疟疾感染个体产生了与SARS-CoV-2刺突蛋白发生交叉反应的高水平抗体。交叉反应抗体特异性识别刺突蛋白N-连接聚糖上的唾液酸部分，且不能中和SARS-CoV-2。血清监测对于监测和预测大流行期间的疾病负担及风险至关重要；然而，在疟疾流行国家，常规使用基于刺突蛋白的检测方法可能会高估SARS-CoV-2暴露情况和人群水平的免疫力。
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