硝苯地平与子痫前期中的血小板

Nifedipine and platelets in preeclampsia.

作者信息

Rubin P C, Butters L, McCabe R

机构信息

Department of Materia Medica, University of Glasgow, Scotland.

出版信息

Am J Hypertens. 1988 Apr;1(2):175-7. doi: 10.1093/ajh/1.2.175.

DOI:10.1093/ajh/1.2.175

PMID:3401356

Abstract

In addition to its antihypertensive properties, nifedipine inhibits platelet aggregation in vitro. Because increased platelet aggregation is a feature of preeclampsia, we have investigated nifedipine in this condition. Ten women at 31 +/- 2.8 weeks gestation, with blood pressure 162 +/- 18/102 +/- 10 mmHg (despite atenolol 200 mg/day) and proteinuria 2.0 +/- 1.1 g/24 hr, were treated with nifedipine. Pregnancies were prolonged by 17 +/- 15 days (range 5 to 56). Blood pressure was controlled in eight of the ten patients, final values before delivery being 142 +/- 16/89 +/- 12 mmHg (P less than 0.02). Platelet count rose in all women from 190 +/- 80 to 261 +/- 78 X 10(9)/1 (P less than 0.001). Nifedipine appears to reverse the thrombocytopenia of pre-eclampsia, in addition to controlling the blood pressure.

摘要

除具有降压特性外，硝苯地平在体外还能抑制血小板聚集。由于血小板聚集增加是先兆子痫的一个特征，我们对硝苯地平在这种情况下的作用进行了研究。10名妊娠31±2.8周的妇女，血压为162±18/102±10 mmHg（尽管每天服用阿替洛尔200 mg），蛋白尿为2.0±1.1 g/24小时，接受了硝苯地平治疗。孕期延长了17±15天（范围为5至56天）。10名患者中有8名血压得到控制，分娩前的最终血压值为142±16/89±12 mmHg（P<0.02）。所有女性的血小板计数从190±80升至261±78×10⁹/L（P<0.001）。硝苯地平除了能控制血压外，似乎还能逆转先兆子痫的血小板减少症。