Laboratoire de Recherche Bioressources: Biologie Intégrative & Valorisation, Université de Monastir, Monastir, Tunisia.
Laboratory of Histology and Cytogenetic, Faculty of Medicine, Monastir, Tunisia.
Hum Exp Toxicol. 2021 Nov;40(11):1998-2011. doi: 10.1177/09603271211013448. Epub 2021 May 20.
Phytochemical composition and antioxidant activity of flowers decoction at post-flowering stage (F3D) of were determined. The obtained findings demonstrate that F3D has a marked antioxidant activity in all tested assays. Furthermore, the present study was designed to test the protective activity of F3D against induced Diabetes type 2 (DT2) in male rats. Those metabolic syndromes were induced by a high-fructose diet (HFD) (10% fructose solution) for a period of 20 weeks. F3D was administered orally (100 and 300 mg/kg body weight) daily for the last 4 weeks. Metformin (150 mg/kg body weight) was used as a standard drug and administrated orally for the last 4 weeks. The results showed a significant increase in blood glucose, triglycerides and hepatic markers (ALAT, ASAT and ALK-P) in HFD group. A significant increase in hepatic TBARS and a significant decrease in SOD, CAT and GP were observed in fructose fed rats compared to control group. Administration of F3D showed a protective effect in biochemical and oxidative stress parameters measured in this study. Also, oral administration of F3D restored the histological architecture of rat liver in comparison with rats fed HFD. In conclusion, F3D attenuated hepatic oxidative stress in fructose-fed rats.
研究测定了开花后期（F3D）的花煎剂的植物化学成分和抗氧化活性。研究结果表明，F3D 在所有测试中均具有明显的抗氧化活性。此外，本研究旨在测试 F3D 对雄性大鼠诱导的 2 型糖尿病（DT2）的保护活性。代谢综合征是通过高果糖饮食（HFD）（10%果糖溶液）喂养 20 周引起的。F3D 每天口服（100 和 300mg/kg 体重），共 4 周。二甲双胍（150mg/kg 体重）用作标准药物，并口服 4 周。结果表明，HFD 组的血糖、甘油三酯和肝标志物（ALAT、ASAT 和 ALK-P）显著升高。与对照组相比，果糖喂养的大鼠肝组织 TBARS 显著增加，SOD、CAT 和 GP 显著降低。F3D 的给药对本研究中测量的生化和氧化应激参数具有保护作用。此外，与 HFD 喂养的大鼠相比，F3D 的口服给药恢复了大鼠肝脏的组织学结构。总之，F3D 减轻了果糖喂养大鼠的肝氧化应激。
