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Beovu, but not Lucentis impairs the function of the barrier formed by retinal endothelial cells in vitro.贝伐珠单抗（Beovu）会损害体外培养的视网膜内皮细胞形成的屏障功能，但雷珠单抗（Lucentis）不会。
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Swept-source optical coherence tomography angiography of retinal occlusive vasculitis following brolucizumab administration: a case report.接受布罗利珠单抗治疗后视网膜阻塞性血管炎的扫频源光学相干断层扫描血管造影：病例报告。
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Initial Pro Re Nata Brolucizumab for Exudative AMD: The PROBE Study.初始按需使用布罗珠单抗治疗渗出性年龄相关性黄斑变性：PROBE研究。
J Clin Med. 2021 Sep 15;10(18):4153. doi: 10.3390/jcm10184153.

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Brolucizumab-related retinal vasculitis with exacerbation following ranibizumab retreatment: A clinicopathologic case study.布罗鲁单抗相关的视网膜血管炎伴雷珠单抗再次治疗后病情加重：一项临床病理病例研究。
Am J Ophthalmol Case Rep. 2020 Nov 10;20:100989. doi: 10.1016/j.ajoc.2020.100989. eCollection 2020 Dec.
2
Risk of Inflammation, Retinal Vasculitis, and Retinal Occlusion-Related Events with Brolucizumab: Post Hoc Review of HAWK and HARRIER.Brolucizumab 相关炎症、视网膜血管炎和视网膜阻塞相关事件的风险：HAWK 和 HARRIER 的事后回顾。
Ophthalmology. 2021 Jul;128(7):1050-1059. doi: 10.1016/j.ophtha.2020.11.011. Epub 2020 Nov 15.
3
Expert Opinion on Management of Intraocular Inflammation, Retinal Vasculitis, and Vascular Occlusion after Brolucizumab Treatment.关于布罗利珠单抗治疗后眼内炎症、视网膜血管炎和血管闭塞管理的专家意见
Ophthalmol Retina. 2021 Jun;5(6):519-527. doi: 10.1016/j.oret.2020.09.020. Epub 2020 Sep 29.
4
Occlusive Retinal Vasculitis Following Intravitreal Brolucizumab.玻璃体内注射布罗珠单抗后发生的视网膜血管阻塞性血管炎
J Vitreoretin Dis. 2020 Jul;4(4):269-279. doi: 10.1177/2474126420930863. Epub 2020 Jul 1.
5
Retinal Vasculitis and Intraocular Inflammation after Intravitreal Injection of Brolucizumab.眼内注射布罗鲁单抗后视网膜血管炎和眼内炎症。
Ophthalmology. 2020 Oct;127(10):1345-1359. doi: 10.1016/j.ophtha.2020.04.017. Epub 2020 Apr 25.
6
Severe vision loss secondary to retinal arteriolar occlusions after multiple intravitreal brolucizumab administrations.多次玻璃体内注射布罗珠单抗后继发视网膜小动脉阻塞导致严重视力丧失。
Am J Ophthalmol Case Rep. 2020 Apr 2;18:100687. doi: 10.1016/j.ajoc.2020.100687. eCollection 2020 Jun.
7
Retinal arterial occlusive vasculitis following intravitreal brolucizumab administration.玻璃体内注射布罗珠单抗后发生的视网膜动脉闭塞性血管炎。
Am J Ophthalmol Case Rep. 2020 Mar 31;18:100680. doi: 10.1016/j.ajoc.2020.100680. eCollection 2020 Jun.
8
Brolucizumab and immunogenicity.布罗鲁单抗与免疫原性。
Eye (Lond). 2020 Oct;34(10):1726-1728. doi: 10.1038/s41433-020-0853-9. Epub 2020 Apr 6.
9
Brolucizimab-leading an era of structural revolution for long-term VEGF suppression.布罗鲁单抗——引领长期抑制血管内皮生长因子的结构革命时代。
Eye (Lond). 2020 Apr;34(4):611-613. doi: 10.1038/s41433-019-0583-z. Epub 2019 Sep 19.
10
Brolucizumab: is extended VEGF suppression on the horizon?布罗利珠单抗：长效血管内皮生长因子抑制即将实现？
Eye (Lond). 2020 Mar;34(3):424-426. doi: 10.1038/s41433-019-0582-0. Epub 2019 Sep 16.

Understanding Retinal Vasculitis Associated with Brolucizumab: Complex Pathophysiology or Occam's Razor?

作者信息

Sharma Ashish, Kumar Nilesh, Parachuri Nikulaa, Singh Sonali, Bandello Francesco, Regillo Carl D, Boyer David, Nguyen Quan Dong

机构信息

Lotus Eye Hospital and Institute, Coimbatore, India.

Ocular Pathologist, Madhavi Netralaya, Ara, India.

出版信息

Ocul Immunol Inflamm. 2022 Aug;30(6):1508-1510. doi: 10.1080/09273948.2021.1897628. Epub 2021 May 20.

DOI:10.1080/09273948.2021.1897628
PMID:34014141
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10919544/
Abstract
摘要