玻璃体内注射法西单抗继发双侧闭塞性视网膜血管炎：一例报告并文献复习
Bilateral occlusive retinal vasculitis secondary to intravitreal faricimab injection: a case report and review of literature.
作者信息
Lee Yong Min, Gurung Rajya, Gilhotra Jagjit Singh, Simon Sumu, Cugati Sudha
机构信息
Ophthalmology Department, Royal Adelaide Hospital, Port Road, Adelaide, SA, 5000, Australia.
Ophthalmology Department, Modbury Hospital, Adelaide, SA, 5069, Australia.
出版信息
Eye Vis (Lond). 2024 Dec 3;11(1):48. doi: 10.1186/s40662-024-00416-y.
BACKGROUND
This article describes a rare occurrence of bilateral retinal occlusive vasculitis secondary to intravitreal faricimab injection.
CASE PRESENTATION
A 72-year-old female with age-related macular degeneration presented with bilateral retinal occlusive vasculitis following intravitreal faricimab injections. The patient was treated with 3 days of intravenous methylprednisolone followed by oral prednisolone taper and topical steroid therapy. Resolution of retinal occlusive vasculitis was observed 2 months post treatment.
CONCLUSIONS
Retinal occlusive vasculitis is a rare complication of intravitreal anti-vascular endothelial growth factor (anti-VEGF), particularly with faricimab injections. We also present a review of literature regarding retinal occlusive vasculitis following intravitreal anti-VEGF injections and propose further information regarding its pathophysiology.
背景
本文描述了玻璃体内注射法西单抗继发双侧视网膜闭塞性血管炎这一罕见病例。
病例介绍
一名72岁患有年龄相关性黄斑变性的女性在玻璃体内注射法西单抗后出现双侧视网膜闭塞性血管炎。患者接受了3天的静脉注射甲泼尼龙治疗，随后逐渐减量口服泼尼松龙并进行局部类固醇治疗。治疗后2个月观察到视网膜闭塞性血管炎消退。
结论
视网膜闭塞性血管炎是玻璃体内抗血管内皮生长因子（抗VEGF）治疗的罕见并发症，尤其是在注射法西单抗时。我们还对玻璃体内注射抗VEGF后发生视网膜闭塞性血管炎的文献进行了综述，并提出了关于其病理生理学的更多信息。
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