Department of Healh Science, Federal University of São João Del-Rei (UFSJ), Divinópolis, Minas Gerais, Brazil.
Center of Clinical and Epidemiological Research, University Hospital, University of Sao Paulo, Sao Paulo, Brazil.
Eur J Clin Pharmacol. 2021 Nov;77(11):1725-1735. doi: 10.1007/s00228-021-03156-3. Epub 2021 May 20.
The study aims to investigate the longitudinal association of use and time of use of proton pump inhibitors (PPIs) with decreased performance in three cognitive tests.
Prospective cohort study included 7115 participants with mean age of 58.9 years at baseline (2008-2010) who participated in the second wave (2012-2014) of ELSA-Brasil (average interval between visits = 3.9 years (range: 1.7 to 6.0 years)). Cognitive performance was assessed by tests of memory, phonemic and semantic verbal fluency, and the trail making test, applied to both waves. Associations with the use and time of use of PPIs at baseline were investigated using linear models with mixed effects after adjusting for confounding factors.
At baseline, 7.4% (529) of the participants used PPIs on a regular basis. After all adjustments, the interaction term use of PPI × age was not statistically significant for the cognitive tests evaluated, indicating that the use of PPI at baseline was not associated with a more accelerated decline in cognitive performance between waves. The interaction term PPI use × age was not statistically significant, in any of the categories of medication use time, any of the cognitive function tests evaluated, indicating that PPI use time is not associated with decrease in cognitive scores as the time interval between visits increases.
In this cohort middle-aged and elderly adults, after average interval of 3.9 years (relatively short time to detect cognitive decline in a young cohort), the use and time of use of PPIs at the beginning of the study were not associated with a decline in cognitive performance in these tests between visits.
本研究旨在探讨质子泵抑制剂（PPIs）的使用和使用时间与三种认知测试中表现下降的纵向关联。
本前瞻性队列研究纳入了 7115 名平均年龄为 58.9 岁的参与者（基线时为 2008-2010 年），他们参加了巴西 ELSA 研究的第二波（2012-2014 年）（两次访问之间的平均间隔为 3.9 年（范围：1.7 至 6.0 年））。认知表现通过记忆测试、语音和语义流畅性测试以及连线测试进行评估，这些测试在两次访问中都进行了应用。使用混合效应线性模型，在调整混杂因素后，对基线时使用 PPI 和使用时间与 PPI 的关联进行了调查。
基线时，7.4%（529 人）的参与者定期使用 PPIs。在所有调整后，认知测试评估中 PPI 使用与年龄的交互项无统计学意义，表明基线时使用 PPI 与两次访问之间认知表现的加速下降无关。在任何药物使用时间类别、任何认知功能测试中，PPI 使用与年龄的交互项均无统计学意义，表明 PPI 使用时间与随随访间隔增加认知评分下降无关。
在本队列中，中年和老年人在平均间隔 3.9 年后（在年轻队列中检测认知下降的时间相对较短），研究开始时 PPI 的使用和使用时间与这些测试中两次访问之间的认知表现下降无关。
