Postgraduate Program in Health Sciences, Universidade Federal de São João del-Rei, Sebastião Gonçalves Coelho Street, 400 - Chanadour, Divinópolis, 35501-296, MG, Brazil.
Longitudinal Study of Adult Health - ELSA-Brasil, Medical School & Clinical Hospital/EBSERH, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
BMC Nephrol. 2023 Sep 28;24(1):285. doi: 10.1186/s12882-023-03300-4.
Investigate the longitudinal association of use and time of use of proton pump inhibitors (PPI) with incidence of chronic kidney disease (CKD) and kidney function change.
Prospective study with 13,909 participants from baseline (2008-2010) and second wave (2012-2014) of the ELSA-Brasil (mean interval between visits = 3.9 years (1.7-6.0)). Participants answered about use and time use of the PPI in the two weeks prior the interview. Renal function was assessed by glomerular filtration rate estimated by the Collaboration Equation for the Epidemiology of Chronic Kidney Disease. Values below 60ml/min/1.73 m² in wave 2 were considered incident CKD. Associations between PPI use and time of use at baseline and incident CKD and decline in renal function were estimated, respectively, by logistic regression and linear models with mixed effects, after adjusting for confounders.
After adjustments, PPI users for more than six months had an increased risk of CKD compared to non-users. Compared to non-users, users PPIs for up to six months and above six months had greater decline in kidney function over time.
This cohort of adults and elderly, after a mean interval of 3.9 years, PPI use and initial duration were associated with kidney function change between visits.
研究质子泵抑制剂 (PPI) 的使用和使用时间与慢性肾脏病 (CKD) 发病率和肾功能变化的纵向关联。
这项前瞻性研究纳入了来自 ELSA-Brasil（基线和第二轮调查时间分别为 2008-2010 年和 2012-2014 年）的 13909 名参与者（两次随访的平均间隔为 3.9 年[1.7-6.0]）。参与者在两次访谈之间的两周内回答了 PPI 的使用和使用时间。肾小球滤过率通过合作方程进行评估，以估计慢性肾脏病的流行病学。第二轮中低于 60ml/min/1.73m²的数值被认为是 CKD 的发病事件。在调整了混杂因素后，分别使用逻辑回归和混合效应线性模型来估计 PPI 使用和基线时的使用时间与 CKD 发病和肾功能下降之间的关系。
经过调整后，与非使用者相比，使用 PPI 超过六个月的人患 CKD 的风险增加。与非使用者相比，使用 PPI 时间在六个月及以上的患者肾功能随时间的下降更为明显。
这项纳入成年人和老年人的队列研究在平均 3.9 年的随访后发现，PPI 的使用和初始持续时间与两次随访之间的肾功能变化有关。
