邻苯二甲酸酯暴露的胎盘结局。
Placental outcomes of phthalate exposure.
机构信息
Dept of Comparative Biosciences, University of Illinois, Urbana, IL, USA.
Dept of Morphology, Federal University of Espirito Santo, Brazil.
出版信息
Reprod Toxicol. 2021 Aug;103:1-17. doi: 10.1016/j.reprotox.2021.05.001. Epub 2021 May 17.
Abstract
Proper placental development and function relies on hormone receptors and signaling pathways that make the placenta susceptible to disruption by endocrine disrupting chemicals, such as phthalates. Here, we review relevant research on the associations between phthalate exposures and dysfunctions of the development and function of the placenta, including morphology, physiology, and genetic and epigenetic effects. This review covers in vitro studies, in vivo studies in mammals, and studies in humans. We also discuss important gaps in the literature. Overall, the evidence indicates that toxicity to the placental and maternal-fetal interface is associated with exposure to phthalates. Further studies are needed to better elucidate the mechanisms through which phthalates act in the placenta as well as additional human studies that assess placental disruption through pregnancy with larger sample sizes.
摘要
适当的胎盘发育和功能依赖于激素受体和信号通路，这些受体和通路使胎盘容易受到内分泌干扰化学物质（如邻苯二甲酸酯）的干扰。在这里，我们回顾了有关邻苯二甲酸酯暴露与胎盘发育和功能障碍相关的研究，包括形态、生理学以及遗传和表观遗传效应。这篇综述涵盖了体外研究、哺乳动物体内研究和人类研究。我们还讨论了文献中的重要空白。总的来说，有证据表明，胎盘和母体-胎儿界面的毒性与邻苯二甲酸酯的暴露有关。需要进一步的研究来更好地阐明邻苯二甲酸酯在胎盘内的作用机制，以及更多的通过更大样本量的妊娠评估胎盘损伤的人类研究。
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