Kryzhanovskiĭ G N, Krupina N A
Biull Eksp Biol Med. 1988 Jul;106(7):10-4.
Penicillin administration into the bed nucleus of stria terminalis (BNST) in the rat brain caused epileptiform activity (EpA)--the formation of the generator of pathologically enhanced excitation (GPEE) in the nucleus. GPEE was registered during the first 3 days. EpA was also detected in the amygdala during 5-8 days, and in the hippocamp during the whole period of registration (2-3 weeks). There was the generalized enhancement of synchronized EpA in the range of 6-10 oscillations per s., in some cases with high-amplitude spindle (7-8 oscillations per s.). 50% of animals had emotional behavioural disorders, a marked fear reaction was observed for a month and more. Some animals demonstrated psychotic-like paroxysms with the elements of stereotypy accompanied by high-frequency low-amplitude EpA. It is suggested that when a primary GPEE in BNST is formed, the structures of septo-hippocampal system (BNST, amygdala, hippocamp) play a role of pathological determinants under the influence of which the pathological system consisting of a number of limbic and extrapyramidal structures is formed. Its activity is clinically manifested in the complex polymorphic neuropathological syndrome.
向大鼠脑内终纹床核（BNST）注射青霉素会引发癫痫样活动（EpA）——该核内病理性增强兴奋发生器（GPEE）的形成。在最初3天记录到了GPEE。在5 - 8天期间杏仁核中也检测到了EpA，并且在整个记录期（2 - 3周）海马中都能检测到EpA。在每秒6 - 10次振荡范围内出现了同步EpA的普遍增强，在某些情况下伴有高幅纺锤波（每秒7 - 8次振荡）。50%的动物出现了情绪行为障碍，在长达一个月及更长时间内观察到明显的恐惧反应。一些动物表现出类似精神病的发作，伴有刻板动作成分，并伴有高频低幅EpA。研究表明，当BNST中形成原发性GPEE时，隔 - 海马系统结构（BNST、杏仁核、海马）起到病理决定因素的作用，在其影响下由许多边缘和锥体外系结构组成的病理系统得以形成。其活动在临床上表现为复杂的多形性神经病理综合征。
