Gankina E M, Gol'dina O A, Shamakina I Iu, Demurov E A, Koloskov Iu B
Biull Eksp Biol Med. 1988 Jul;106(7):61-4.
Kinetic parameters of monoamine deamination processes in the rat brain and heart after hyperbaric oxygenation (HBO) in toxic conditions (6 ata) were studied. HBO was shown to cause a substantial reduction in MAO affinity to serotonin in the brain, but not in the heart. Contrastingly, MAO affinity to dopamine was found to decrease in the heart, but not in the brain in response to HBO. Differences of tyramine and 2-phenylethylamine deamination in the rat brain and heart were also reciprocal following toxic HBO. In the initial phase of seizure episode MAO activity in the brain and heart was also different. Distinct mechanisms of adaptation to toxic oxygen in the central nervous system and cardiovascular system are discussed.
研究了在中毒条件（6个绝对大气压）下高压氧疗（HBO）后大鼠脑和心脏中单胺脱氨过程的动力学参数。结果表明，HBO可使脑中MAO对血清素的亲和力大幅降低，但对心脏无此作用。相反，发现心脏中MAO对多巴胺的亲和力因HBO而降低，但脑中未出现这种情况。在中毒性HBO后，大鼠脑和心脏中酪胺和2-苯乙胺脱氨的差异也是相反的。癫痫发作初期，脑和心脏中的MAO活性也有所不同。文中讨论了中枢神经系统和心血管系统对中毒性氧的不同适应机制。
Zotero 插件