Gol'dina O A, Tepliakov V G, Demurov E A, Koloskov Iu B, Zagorevskiĭ V A
Biull Eksp Biol Med. 1987 Oct;104(10):469-71.
The reversible MAO-A inhibitor moclobemide (5 mg/kg) was shown to prevent seizures in rats during exposure to toxic oxygen (6 ata). Benzamide derivatives increased the latent period of oxygen seizures and decreased the lethality following hyperbaric oxygenation. The range of anti-MAO activity of moclobemide and clorgyline in the rat brain and heart after toxic oxygenation was studied. It was distinct from those in control animals. Clorgyline was found to be more active in inhibiting MAO during toxic oxygenation in the heart and moclobemide-in the brain. The possibility is shown to prevent oxygen seizures not only with irreversible MAO-A inhibitors (clorgyline), but also with reversible ones (moclobemide).
可逆性单胺氧化酶-A抑制剂吗氯贝胺（5毫克/千克）已被证明可预防大鼠在暴露于有毒氧气（6个绝对大气压）期间发生癫痫。苯甲酰胺衍生物延长了氧气诱发癫痫的潜伏期，并降低了高压氧疗后的致死率。研究了吗氯贝胺和氯吉兰在大鼠脑和心脏经有毒氧合后的抗单胺氧化酶活性范围。它与对照动物的不同。发现氯吉兰在心脏经有毒氧合期间抑制单胺氧化酶更具活性，而吗氯贝胺在脑中更具活性。研究表明，不仅不可逆性单胺氧化酶-A抑制剂（氯吉兰），而且可逆性抑制剂（吗氯贝胺）都有可能预防氧气诱发的癫痫。
