[氧中毒惊厥期大鼠组织中单胺氧化酶和二胺氧化酶的活性]
[Monoamine oxidase and diamine oxidase activity of the tissues of rats in the convulsive phase of oxygen poisoning].
作者信息
Goroshinskaia I A, Khodakova A A, Korobova L N, Frenkel' M L, Nemashkalova L A
出版信息
Nauchnye Doki Vyss Shkoly Biol Nauki. 1984(11):20-4.
Monoamine oxidase type A activity with substrate serotonine and type B with substrate p-nitrophenylethylamine decreases is rats' brain, liver, heart and blood during oxygen convulsions. Substrate specificity of the enzyme type A alters in all tissues studied. Diamine oxidase activity decreases in brain, lungs and liver approximately in 2 times and increases in blood at 48%. Histamine content increases in all tissues in 3-4 times, in blood--in 12 times. The role of observed changes in the mechanism of oxygen intoxication is discussed.
在氧气惊厥期间，以血清素为底物的A型单胺氧化酶活性以及以对硝基苯乙胺为底物的B型单胺氧化酶活性在大鼠的脑、肝、心脏和血液中均降低。在所有研究的组织中，A型酶的底物特异性发生改变。二胺氧化酶活性在脑、肺和肝脏中大约降低2倍，而在血液中增加48%。组胺含量在所有组织中增加3 - 4倍，在血液中增加12倍。讨论了所观察到的变化在氧中毒机制中的作用。
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