Department of Ophthalmology, Show Chwan Memorial Hospital, Changhua, Taiwan.
Department of Ophthalmology, Chang Gung Memorial Hospital, Keelung, Taiwan.
Ophthalmic Epidemiol. 2022 Jun;29(3):302-309. doi: 10.1080/09286586.2021.1925306. Epub 2021 May 20.
To evaluate the association between obstructive sleep apnea (OSA) and central serous chorioretinopathy (CSCR).
A retrospective, cohort, longitudinal study was conducted using the national health insurance database in Taiwan between 1996 and 2013. Patients diagnosed with OSA were enrolled after exclusion, and a control group with similar age, gender, and major systemic co-morbidities were included in a 1:1 ratio by propensity score matching. The primary outcome is the occurrence of CSCR, and patients with CSCR were categorized via severity for further analysis. The percentage of incident CSCR in the OSA group and control groups and the adjusted hazard ratios (aHR) of CSCR were determined by Cox proportional hazard regression.
There were 13,084 patients enrolled in both the OSA group and control groups, respectively. The total event of CSCR was 50 (0.4%) in the OSA group and 25 (0.2%) in the control group ( < .001). Moreover, the OSA group has an increased aHR of 1.9 ( = .012) for developing CSCR. In the subgroup analysis, patients with OSA aged from 30 to 39 and 50 to 59 demonstrated higher risk of developing CSCR compared to the control group, and the presence of OSA would lead to a higher incidence of mild CSCR (all < .05).
OSA patients aged from 30 to 39 and 50 to 59 have a higher risk of developing CSCR, while the severity of CSCR will not be worsen by OSA.
评估阻塞性睡眠呼吸暂停（OSA）与中心性浆液性脉络膜视网膜病变（CSCR）之间的相关性。
本研究使用台湾地区的全民健康保险数据库进行了一项回顾性、队列、纵向研究，时间范围为 1996 年至 2013 年。在排除 OSA 患者后，纳入了 OSA 患者，并按照倾向评分匹配，以 1:1 的比例纳入了年龄、性别和主要系统性合并症相似的对照组。主要结局是 CSCR 的发生，通过严重程度对 CSCR 患者进行分类，进一步进行分析。通过 Cox 比例风险回归确定 OSA 组和对照组中 CSCR 的发生率以及 CSCR 的调整后的危险比（aHR）。
分别纳入 OSA 组和对照组各 13084 例患者。OSA 组中 CSCR 的总事件数为 50 例（0.4%），对照组为 25 例（0.2%）（ < 0.001）。此外，OSA 组发生 CSCR 的 aHR 增加了 1.9（ = 0.012）。在亚组分析中，年龄在 30-39 岁和 50-59 岁的 OSA 患者发生 CSCR 的风险高于对照组，且 OSA 的存在会导致轻度 CSCR 的发病率更高（均<0.05）。
年龄在 30-39 岁和 50-59 岁的 OSA 患者发生 CSCR 的风险较高，而 OSA 不会使 CSCR 的严重程度恶化。
