Division of Infectious Diseases, Institute of Human Virology, University of Maryland School of Medicine, 725 West Lombard Street, Baltimore, MD 21201, USA.
Division of Infectious Diseases, Institute of Human Virology, University of Maryland School of Medicine, 725 West Lombard Street, Baltimore, MD 21201, USA.
Infect Dis Clin North Am. 2021 Jun;35(2):493-514. doi: 10.1016/j.idc.2021.03.012.
Cryptococcosis is an invasive fungal infection of global significance caused by yeasts of the genus Cryptococcus. The prevalence of HIV in certain areas of the world and the expanding population of immunocompromised patients contribute to the ongoing global disease burden. Point-of-care serologic testing has allowed for more rapid diagnosis and implementation of screening programs in resource-limited settings. Management involves therapy aimed at reduction in fungal burden, maintenance of intracranial pressure, and optimization of host immunity. Despite diagnostic and therapeutic advances, cryptococcosis continues to be a disease with unacceptably high incidence and mortality, particularly in resource-limited settings.
cryptococcosis 是一种具有全球意义的侵袭性真菌感染，由 cryptococcus 属的酵母引起。在世界某些地区 HIV 的流行和免疫功能低下患者人数的增加导致了持续的全球疾病负担。即时检测血清学检测使得在资源有限的环境中能够更快地诊断和实施筛查计划。管理包括旨在减少真菌负担、维持颅内压和优化宿主免疫的治疗。尽管在诊断和治疗方面取得了进展，但 cryptococcosis 仍然是一种发病率和死亡率都很高的疾病，尤其是在资源有限的环境中。
