Kumaran B, Gunasekar P G, Aruldhas M M, Govindarajulu P
Department of Endocrinology, University of Madras, Taramani, India.
Brain Res. 1988 May 31;450(1-2):325-33. doi: 10.1016/0006-8993(88)91571-5.
The influence of prolactin (Prl) and bromocriptine on the specific activities of neural and glial cellular enzymes involved in carbohydrate metabolism in cerebral cortex, hypothalamus, cerebellum and pons-medulla was studied. Both Prl and bromocriptine stimulated the activity of hexokinase (HK) in the neural as well as in the glial cells. While Prl increased the activity of phosphofructokinase (PFK), glyceraldehyde-3-phosphate dehydrogenase (G-3-PDH) and pyruvate kinase (PK) in the neural cells, it decreased the same in the glial cells. On the other hand, bromocriptine elevated the activity of all these enzymes in the neural cells without any effect on the glial cells. The activities of neural cellular glucose-6-phosphate dehydrogenase (G-6-PDH) and 6-phosphogluconate dehydrogenase (6-PGDH) were inhibited by Prl, whereas bromocriptine increased the same. The activities of these enzymes in the glial cells were enhanced by both Prl and bromocriptine. Thus, the present study suggests that Prl has a differential effect on the activities of enzymes involved in Embden-Meyerhoff pathway (EMP) and hexosemonophosphate shunt (HMP) in the neural and glial cells of immature male bonnet monkeys.
研究了催乳素（Prl）和溴隐亭对未成熟雄性帽猴大脑皮层、下丘脑、小脑和脑桥-延髓中参与碳水化合物代谢的神经和胶质细胞酶比活性的影响。Prl和溴隐亭均刺激神经细胞和胶质细胞中己糖激酶（HK）的活性。Prl增加神经细胞中磷酸果糖激酶（PFK）、甘油醛-3-磷酸脱氢酶（G-3-PDH）和丙酮酸激酶（PK）的活性，而在胶质细胞中则降低这些酶的活性。另一方面，溴隐亭提高神经细胞中所有这些酶的活性，而对胶质细胞没有任何影响。Prl抑制神经细胞中葡萄糖-6-磷酸脱氢酶（G-6-PDH）和6-磷酸葡萄糖酸脱氢酶（6-PGDH）的活性，而溴隐亭则增加其活性。Prl和溴隐亭均增强胶质细胞中这些酶的活性。因此，本研究表明，Prl对未成熟雄性帽猴神经和胶质细胞中参与糖酵解途径（EMP）和磷酸戊糖途径（HMP）的酶活性具有不同的影响。
