Alvarez E O, Banzan A M
Laboratorio de Investigaciones Cerebrales (LINCE-CONICET), Mendoza, Argentina.
J Neural Transm Gen Sect. 1994;95(1):17-28. doi: 10.1007/BF01283027.
The probable behavioural effects of rat prolactin (rPRL) locally applied into the ventral hippocampus (HPC) were studied in cycling female rats. Three experiments were performed examining the behavioural responses of rats subjected to three different situations: (i) Exploratory activity in an enriched holeboard (ii) exploratory activity under conflicting situation and (iii) escape behaviours in a forced swimming test. Behavioural parameters studied were: underground and object-directed exploration and locomotion (Experiment 1); latency time and exploration behaviours (Experiment 2); swimming time and escape behaviours (Experiment 3). In Experiment 1 results showed that rPRL decreased the underground exploration and also locomotion but increased the object-directed exploration and had no effect on non-ambulatory activity. In Experiment 2 results showed that treatment of rPRL increased the latency time but did not modify the exploratory activity. In Experiment 3 results showed that rPRL augmented the swimming time and one of two parameters (frequency of immersions intents) of the escape behaviour. Results are interpreted as local actions of PRL on hippocampal neuron affecting expression of behaviours of rats depending on the stressful conditions of the environment.
研究了向处于发情周期的雌性大鼠腹侧海马局部注射大鼠催乳素（rPRL）可能产生的行为影响。进行了三项实验，考察大鼠在三种不同情况下的行为反应：（i）在丰富的洞板中的探究活动；（ii）冲突情境下的探究活动；（iii）强迫游泳试验中的逃避行为。所研究的行为参数包括：地下探索和目标导向探索及运动（实验1）；潜伏期和探索行为（实验2）；游泳时间和逃避行为（实验3）。实验1结果显示，rPRL减少了地下探索和运动，但增加了目标导向探索，且对非移动活动无影响。实验2结果显示，rPRL处理增加了潜伏期，但未改变探索活动。实验3结果显示，rPRL延长了游泳时间，并增加了逃避行为的两个参数之一（浸入意图频率）。结果被解释为PRL对海马神经元的局部作用，根据环境的应激条件影响大鼠行为表达。
