Zhai Yanping, Pan Jiayu, Zhang Chunyun
Department of Intensive Care Medicine, The Fifth Affiliated Hospital of Guangzhou Medical University Guangzhou 510000, Guangdong, China.
Am J Transl Res. 2021 Apr 15;13(4):3839-3844. eCollection 2021.
This study explored and analyzed the application value of oXiris- endotoxin adsorption technology in patients with sepsis.
23 sepsis patients hospitalized from January 2018 to September 2019 in our ICU center and received oxiris-endotoxin adsorption were enrolled as the observation group, and another 30 sepsis patients hospitalized during the same period were selected as the control group who treated with routine continuous renal replacement therapy (CRRT). The heart rate, respiratory rate, norepinephrine (NE) dosage, lactic acid, procalcitonin (PCT), urine volume, and sofa scores that evaluate organ failure after systemic infection, as well as ICU stay, organ support duration, and incidence of cardiovascular events were compared between the two groups before and after treatment.
The heart rate, respiratory rate and NE dosage of the two groups post-treatment were dramatically lower than those pre-treatment (), and these indexes in observation group after treatment were critically lower than those in control group (). The lactic acid, PCT, urine volume and sofa scores of the two groups were dramatically lower than those before treatment (), and the indexes in observation group after treatment were notably lower than those in control group (). The degree of serum IL-6, IL-10 and endotoxin in two groups after operation decreased remarkably than that before treatment (), and the observation group had obviously lower indicator degree than the control group (). The ICU stay, organ support duration, and incidence of cardiovascular events in the observation group were notably lower than those in the control group ().
compared with the traditional CRRT technology, the oXiris membrane based CRRT technology can effectively improve the hemodynamic indicators of patients with sepsis, reduce the level of inflammation, and improve the metabolic function of body, thereby improving the patients' organ function. It has good clinical application value in patients with sepsis.
本研究探讨并分析oXiris内毒素吸附技术在脓毒症患者中的应用价值。
选取2018年1月至2019年9月在我院ICU中心住院并接受oXiris内毒素吸附治疗的23例脓毒症患者作为观察组，另选取同期住院的30例接受常规连续性肾脏替代治疗（CRRT）的脓毒症患者作为对照组。比较两组治疗前后的心率、呼吸频率、去甲肾上腺素（NE）用量、乳酸、降钙素原（PCT）、尿量以及评估全身感染后器官功能衰竭的序贯器官衰竭评估（SOFA）评分，以及ICU住院时间、器官支持时间和心血管事件发生率。
两组治疗后的心率、呼吸频率和NE用量均显著低于治疗前（），且观察组治疗后的这些指标显著低于对照组（）。两组的乳酸、PCT、尿量和SOFA评分均显著低于治疗前（），且观察组治疗后的指标显著低于对照组（）。两组术后血清白细胞介素-6（IL-6）、白细胞介素-10（IL-10）和内毒素水平较治疗前均明显降低（），且观察组指标水平明显低于对照组（）。观察组的ICU住院时间、器官支持时间和心血管事件发生率均显著低于对照组（）。
与传统CRRT技术相比，基于oXiris膜的CRRT技术能有效改善脓毒症患者的血流动力学指标，降低炎症水平，改善机体代谢功能，从而改善患者器官功能。在脓毒症患者中具有良好的临床应用价值。
