Adelman Zach N, Kojin Bianca B
Department of Entomology and AgriLife Research, Texas A&M University, College Station, TX, USA.
J Med Entomol. 2021 Sep 7;58(5):1997-2005. doi: 10.1093/jme/tjab090.
Over the last few decades, a substantial number of anti-malarial effector genes have been evaluated for their ability to block parasite infection in the mosquito vector. While many of these approaches have yielded significant effects on either parasite intensity or prevalence of infection, just a few have been able to completely block transmission. Additionally, many approaches, while effective against the parasite, also disrupt or alter important aspects of mosquito physiology, leading to corresponding changes in lifespan, reproduction, and immunity. As the most promising approaches move towards field-based evaluation, questions of effector gene robustness and durability move to the forefront. In this forum piece, we critically evaluate past effector gene approaches with an eye towards developing a deeper pipeline to augment the current best candidates.
在过去几十年里，大量抗疟效应基因已针对其阻断蚊虫媒介中寄生虫感染的能力进行了评估。虽然这些方法中有许多对寄生虫强度或感染率产生了显著影响，但只有少数能够完全阻断传播。此外，许多方法虽然对寄生虫有效，但也会破坏或改变蚊虫生理学的重要方面，导致寿命、繁殖和免疫力发生相应变化。随着最有前景的方法进入基于现场的评估阶段，效应基因的稳健性和耐久性问题成为了首要关注点。在这篇论坛文章中，我们批判性地评估了过去的效应基因方法，旨在开发一个更深入的流程，以增强当前的最佳候选方案。
